共 120 条
β-Lactoglobulin: An efficient nanocarrier for advanced delivery systems
被引:77
作者:
Shafaei, Zahra
[1
]
Ghalandari, Behafarid
[2
]
Vaseghi, Akbar
[3
]
Divsalar, Adeleh
[1
]
Haertle, Thomas
[4
]
Saboury, Ali Akbar
[5
,6
]
Sawyer, Lindsay
[7
]
机构:
[1] Kharazmi Univ, Fac Biol Sci, Dept Cell & Mol Biol, Tehran, Iran
[2] Islamic Azad Univ, Sci & Res Branch, Appl Biophoton Res Ctr, Tehran, Iran
[3] Fac Adv Sci & Technol Isfahan, Dept Biotechnol, Esfahan, Iran
[4] Inst Natl Rech Agronom, FIP, BIA UR1268, Nantes, France
[5] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran
[6] Univ Tehran, Ctr Excellence Biothermodynam, Tehran, Iran
[7] Univ Edinburgh, Sch Biol Sci, Edinburgh, Midlothian, Scotland
关键词:
beta-lactoglobulin;
Nanocarrier;
Delivery system;
beta-LG nanoparticles;
PECTIN-BASED NANOPARTICLES;
DRUG-DELIVERY;
IN-VITRO;
STRUCTURAL-ANALYSIS;
CIRCULAR-DICHROISM;
BINDING-PROPERTIES;
CONTROLLED-RELEASE;
ANTICANCER DRUG;
COMPLEX;
GELATIN;
D O I:
10.1016/j.nano.2017.03.007
中图分类号:
TB3 [工程材料学];
学科分类号:
0805 ;
080502 ;
摘要:
Thanks to the progress of nanotechnology there are several agent-delivery systems that can be selected to achieve rapid and specific delivery of a wide variety of biologically active agents. Consequently, the manipulation and engineering of biopolymers has become one of the most exciting subjects for those who study delivery systems on the nanoscale. In this regard, both nanoparticle formation and a carrier role have been observed in the case of the globular milk whey protein, beta-lactoglobulin (beta-LG), setting it apart from many other proteins. To date, many efforts adopting different approaches have created beta-LG nanoparticles useful in forming delivery systems for various agents with specific targets. In this review, the potential of beta-LG to play the role of an efficient and diverse carrier protein, as well as its ability to form a well-targeted nano-scale delivery system is discussed. (C) 2017 Elsevier Inc. All rights reserved.
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页码:1685 / 1692
页数:8
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