β-Lactoglobulin: An efficient nanocarrier for advanced delivery systems

被引:77
作者
Shafaei, Zahra [1 ]
Ghalandari, Behafarid [2 ]
Vaseghi, Akbar [3 ]
Divsalar, Adeleh [1 ]
Haertle, Thomas [4 ]
Saboury, Ali Akbar [5 ,6 ]
Sawyer, Lindsay [7 ]
机构
[1] Kharazmi Univ, Fac Biol Sci, Dept Cell & Mol Biol, Tehran, Iran
[2] Islamic Azad Univ, Sci & Res Branch, Appl Biophoton Res Ctr, Tehran, Iran
[3] Fac Adv Sci & Technol Isfahan, Dept Biotechnol, Esfahan, Iran
[4] Inst Natl Rech Agronom, FIP, BIA UR1268, Nantes, France
[5] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran
[6] Univ Tehran, Ctr Excellence Biothermodynam, Tehran, Iran
[7] Univ Edinburgh, Sch Biol Sci, Edinburgh, Midlothian, Scotland
关键词
beta-lactoglobulin; Nanocarrier; Delivery system; beta-LG nanoparticles; PECTIN-BASED NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; STRUCTURAL-ANALYSIS; CIRCULAR-DICHROISM; BINDING-PROPERTIES; CONTROLLED-RELEASE; ANTICANCER DRUG; COMPLEX; GELATIN;
D O I
10.1016/j.nano.2017.03.007
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Thanks to the progress of nanotechnology there are several agent-delivery systems that can be selected to achieve rapid and specific delivery of a wide variety of biologically active agents. Consequently, the manipulation and engineering of biopolymers has become one of the most exciting subjects for those who study delivery systems on the nanoscale. In this regard, both nanoparticle formation and a carrier role have been observed in the case of the globular milk whey protein, beta-lactoglobulin (beta-LG), setting it apart from many other proteins. To date, many efforts adopting different approaches have created beta-LG nanoparticles useful in forming delivery systems for various agents with specific targets. In this review, the potential of beta-LG to play the role of an efficient and diverse carrier protein, as well as its ability to form a well-targeted nano-scale delivery system is discussed. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:1685 / 1692
页数:8
相关论文
共 120 条
  • [1] Dielectric properties of β-lactoglobulin as influenced by pH, concentration and temperature
    Ahmed, Jasim
    Luciano, Giorgio
    [J]. JOURNAL OF FOOD ENGINEERING, 2009, 95 (01) : 30 - 35
  • [2] Stability parameters for β-lactoglobulin thermal dissociation and unfolding in phosphate buffer at pH 7.0
    Apenten, RKO
    Khokhar, S
    Galani, D
    [J]. FOOD HYDROCOLLOIDS, 2002, 16 (02) : 95 - 103
  • [3] Encapsulation of ketoprofen for controlled drug release
    Arida, Adi I.
    Al-Tabakha, Moawia M.
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, 66 (01) : 48 - 54
  • [4] Structure and dynamics of β-lactoglobulin in complex with dodecyl sulfate and laurate: A molecular dynamics study
    Bello, Martiniano
    Gutierrez, Gabriel
    Garcia-Hernandez, Enrique
    [J]. BIOPHYSICAL CHEMISTRY, 2012, 165 : 79 - 86
  • [5] Novel pectin-based nanoparticles prepared from nanoemulsion templates for improving in vitro dissolution and in vivo absorption of poorly water-soluble drug
    Burapapadh, Kanokporn
    Takeuchi, Hirofumi
    Sriamornsak, Pornsak
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 82 (02) : 250 - 261
  • [6] Binding of alkylsulfonate ligands to bovine β-lactoglobulin:: effects on protein denaturation by urea
    Busti, P
    Scarpeci, S
    Gatti, CA
    Delorenzi, NJ
    [J]. FOOD HYDROCOLLOIDS, 2005, 19 (02) : 249 - 255
  • [7] Unfolding diminishes fluorescence resonance energy transfer (FRET) of lysine modified β-lactoglobulin: Relevance towards anti-HIV binding
    Chakraborty, Jishnu
    Das, Niloy
    Halder, Umesh Chandra
    [J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2011, 102 (01) : 1 - 10
  • [8] Cooperative α-helix formation of β-lactoglobulin induced by sodium n-alkyl sulfates
    Chamani, J
    Moosavi-Movahedi, AA
    Rajabi, O
    Gharanfoli, M
    Momen-Heravi, M
    Hakimelahi, GH
    Neamati-Baghsiah, A
    Varasteh, AR
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2006, 293 (01) : 52 - 60
  • [9] Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers
    Champion, Julie A.
    Katare, Yogesh K.
    Mitragotri, Samir
    [J]. JOURNAL OF CONTROLLED RELEASE, 2007, 121 (1-2) : 3 - 9
  • [10] Impact of cosolvents on formation and properties of biopolymer nanoparticles formed by heat treatment of β-lactoglobulin-Pectin complexes
    Chanasattru, Wanlop
    Jones, Owen Griffith
    Decker, Eric A.
    McClements, David Julian
    [J]. FOOD HYDROCOLLOIDS, 2009, 23 (08) : 2450 - 2457