Quantitative MR Imaging of Cartilage and Trabecular Bone in Osteoarthritis

被引：42
作者：
Eckstein, Felix [1 ,2 ]
Guermazi, Ali [3 ,4 ]
Roemer, Frank W. [3 ,5 ]
机构：
[1] Paracelsus Med Univ, Inst Anat & Musculoskeletal Res, A-5020 Salzburg, Austria
[2] Chondrometrics GmbH, Ainring, Germany
[3] Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USA
[4] Boston Imaging Core Lab LLC, Boston, MA USA
[5] Klinikum Augsburg, Dept Radiol, Augsburg, Germany
来源：
RADIOLOGIC CLINICS OF NORTH AMERICA | 2009年 / 47卷 / 04期
关键词：
Osteoarthritis; MR imaging; Cartilage; Trabecular bone; Knee; Progression; Risk factors; Subregional; SYMPTOMATIC KNEE OSTEOARTHRITIS; JOINT-SPACE WIDTH; INITIATIVE PROGRESSION SUBCOHORT; MULTICENTER CLINICAL-TRIAL; MAGNETIC-RESONANCE IMAGES; HUMAN ARTICULAR-CARTILAGE; TEST-RETEST-PRECISION; DIMEGLUMINE GD-DTPA; FIXED-FLEXION; IN-VIVO;
D O I：
10.1016/j.rcl.2009.03.002
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Whereas the strength of scoring systems in osteoarthritis (OA) lies in detecting local changes, involving small parts of the structures of interest (ie, cartilage lesions), quantitative measures are powerful where minute changes occur homogeneously throughout large structures. Cartilage measurements at 1.5 or 3 Tesla are technically accurate, reproducible, and sensitive to change. The rate of change in knee OA was found to be 1% to 2% annually. Risk factors of cartilage loss include a high BMI, meniscal pathology, malalignment, advanced radiographic OA, bone marrow alterations, and focal cartilage lesions. MRI of articular tissues represents a potent tool in experimental, epidemiological and pharmacological intervention studies; however, it is only with the availability of disease modifying drugs that it will play a relevant role in clinical practice.
引用
收藏
页码：655 / +
页数：21
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