Physiological significance of ghrelin revealed by studies using genetically engineered mouse models with modifications in the ghrelin system

被引：0
作者：
Ariyasu, Hiroyuki [1 ]
Akamizu, Takashi [1 ]
机构：
[1] Wakayama Med Univ, Dept Internal Med 1, Wakayama 6418509, Japan
来源：
ENDOCRINE JOURNAL | 2015年 / 62卷 / 11期
基金：
日本学术振兴会;
关键词：
Ghrelin; GROWTH-HORMONE SECRETAGOGUE; DECREASE FOOD-INTAKE; DES-ACYL GHRELIN; HIGH-FAT DIET; INSULIN-SECRETION; CIRCULATING GHRELIN; MESSENGER-RNA; MYOCARDIAL-INFARCTION; PERIPHERAL GHRELIN; NEUROPEPTIDE-Y;
D O I：
10.1507/endocrj.EJ15-0361
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptor (GHS-R or ghrelin receptor), is a 28-amino acid acylated peptide mainly produced in the stomach. The pharmacological administration of ghrelin is known to exert diverse effects, such as stimulating GH secretion, promoting food intake, and increasing adiposity. In recent years, genetically engineered mouse models have provided important insights into the physiology of various hormones. In this review, we discuss current knowledge regarding the physiological significance of ghrelin on the basis of studies using genetically engineered mouse models with modifications in the ghrelin system.
引用
收藏
页码：953 / 963
页数：11
相关论文
共 119 条
  • [1] Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Abizaid, Alfonso
    Liu, Zhong-Wu
    Andrews, Zane B.
    Shanabrough, Marya
    Borok, Erzsebet
    Elsworth, John D.
    Roth, Robert H.
    Sleeman, Mark W.
    Picciotto, Marina R.
    Tschop, Matthias H.
    Gao, Xiao-Bing
    Horvath, Tamas L.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (12) : 3229 - 3239
  • [2] Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats
    Adeghate, E
    Ponery, AS
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2002, 14 (07) : 555 - 560
  • [3] EFFECTS OF GHRELIN TREATMENT ON PATIENTS UNDERGOING TOTAL HIP REPLACEMENT FOR OSTEOARTHRITIS: DIFFERENT OUTCOMES FROM STUDIES IN PATIENTS WITH CARDIAC AND PULMONARY CACHEXIA
    Akamizu, Takashi
    Iwakura, Hiroshi
    Ariyasu, Hiroyuki
    Murayama, Toshinori
    Sumi, Eriko
    Teramukai, Satoshi
    Goto, Koji
    Ohnishi, Eijiro
    Akiyama, Haruhiko
    Kawanabe, Keiichi
    Nankaku, Manabu
    Ichihashi, Noriaki
    Tsuboyama, Tadao
    Tamai, Ken
    Kataoka, Masako
    Nakamura, Takashi
    Kangawa, Kenji
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2008, 56 (12) : 2363 - 2365
  • [4] Transgenic mice overexpressing des-acyl ghrelin show small phenotype
    Ariyasu, H
    Takaya, K
    Iwakura, H
    Hosoda, H
    Akamizu, T
    Arai, Y
    Kangawa, K
    Nakao, K
    [J]. ENDOCRINOLOGY, 2005, 146 (01) : 355 - 364
  • [5] Delayed short-term secretory regulation of ghrelin in obese animals: Evidenced by a specific RIA for the active form of ghrelin
    Ariyasu, H
    Takaya, K
    Hosoda, H
    Iwakura, H
    Ebihara, K
    Mori, K
    Ogawa, Y
    Hosoda, K
    Akamizu, T
    Kojima, M
    Kangawa, K
    Nakao, K
    [J]. ENDOCRINOLOGY, 2002, 143 (09) : 3341 - 3350
  • [6] Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    Ariyasu, H
    Takaya, K
    Tagami, T
    Ogawa, Y
    Hosoda, K
    Akamizu, T
    Suda, M
    Koh, T
    Natsui, K
    Toyooka, S
    Shirakami, G
    Usui, T
    Shimatsu, A
    Doi, K
    Hosoda, H
    Kojima, M
    Kangawa, K
    Nakao, K
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) : 4753 - 4758
  • [7] Reduction in circulating ghrelin concentration after maturation does not affect food intake
    Ariyasu, Hiroyuki
    Yamada, Go
    Iwakura, Hiroshi
    Matsumura, Sigenobu
    Inoue, Kazuo
    Kangawa, Kenji
    Nakao, Kazuwa
    Akamizu, Takashi
    [J]. ENDOCRINE JOURNAL, 2014, 61 (10) : 1041 - 1052
  • [8] Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis
    Ariyasu, Hiroyuki
    Iwakura, Hiroshi
    Yukawa, Naoichiro
    Murayama, Toshinori
    Yokode, Masayuki
    Tada, Harue
    Yoshimura, Kenichi
    Teramukai, Satoshi
    Ito, Tatsuya
    Shimizu, Akira
    Yonezawa, Atsushi
    Kangawa, Kenji
    Mimori, Tsuneyo
    Akamizu, Takashi
    [J]. ENDOCRINE JOURNAL, 2014, 61 (07) : 735 - 742
  • [9] Transgenic Mice Overexpressing Ghrelin or Ghrelin Analog
    Ariyasu, Hiroyuki
    Yamada, Go
    Iwakura, Hiroshi
    Akamizu, Takashi
    Kangawa, Kenji
    Nakao, Kazuwa
    [J]. GHRELIN, 2012, 514 : 371 - 377
  • [10] A Postweaning Reduction in Circulating Ghrelin Temporarily Alters Growth Hormone (GH) Responsiveness to GH-Releasing Hormone in Male Mice But Does Not Affect Somatic Growth
    Ariyasu, Hiroyuki
    Iwakura, Hiroshi
    Yamada, Go
    Kanamoto, Naotetsu
    Bando, Mika
    Kohno, Kenji
    Sato, Takahiro
    Kojima, Masayasu
    Nakao, Kazuwa
    Kangawa, Kenji
    Akamizu, Takashi
    [J]. ENDOCRINOLOGY, 2010, 151 (04) : 1743 - 1750
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