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Development of a Powder Extruder System for Dual-pore Tissue-engineering Scaffold Fabrication
被引:8
|作者:
Kang, Nae-Un
[1
]
Hong, Myoung Wha
[2
]
Kim, Young Yul
[2
]
Cho, Young-Sam
[1
]
Lee, Seung-Jae
[1
]
机构:
[1] Wonkwang Univ, Coll Engn, Dept Mech Design Engn, 460 Iksandae Ro, Iksan Jeonbuk 570749, South Korea
[2] Catholic Univ Korea, Daejeon St Marys Hosp, Dept Orthoped, 64 Daeheung Ro, Daejeon 301723, South Korea
关键词:
dual-pore scaffold;
powder extruder system;
polycaprolactone;
3D tissue-engineering scaffold;
BIODEGRADABLE POLYMER SCAFFOLDS;
POROUS SCAFFOLDS;
POLY(D;
L-LACTIC-CO-GLYCOLIC ACID);
DEGRADATION BEHAVIOR;
GELATIN SCAFFOLDS;
SALT;
BONE;
CARTILAGE;
SPONGES;
D O I:
10.1007/s42235-019-0055-y
中图分类号:
T [工业技术];
学科分类号:
08 ;
摘要:
In this study, we developed a powder extruder system that can extrude and deposit powder mixtures to overcome the reported limitations of conventional dual-pore scaffold manufacturing methods. To evaluate the extrusion and deposition capability of the powder extruder system, 3D tissue-engineering scaffolds with dual-pore characteristics were fabricated with a PCL/PEO/NaCl (polycaprolactone/polyethylene oxide/sodium chloride) powder mixture. In addition, to evaluate the fabricated scaffolds, their compressive modulus, morphology, and in-vitro cell activity were assessed. Consequently, it was confirmed that the proposed powder extruder system can fabricate dual-pore scaffolds with well-interconnected pores as well as arbitrary 3D shapes shown by the fabrication of a 3D femur-shape scaffold similar to the femur model. The results of the cell proliferation and Cell Counting Kit-8 (CCK-8) assays, DNA content analysis and viability assays confirm that the dual-pore scaffold fabricated by the powder extruder system improves cell attachment, proliferation, and viability.
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页码:686 / 695
页数:10
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