A comparative study on the effect of streptokinase between diabetic and non-diabetic myocardial infarction patients

被引：6
作者：
Chowdhury, Md. Anup Rahman [1 ]
Hossain, A. K. M. Mosharrof [1 ]
Dey, Sudhangshu Ranjan [2 ]
Akhtaruzzaman, A. K. M. [2 ]
Islam, Nur-A-Farhana [3 ]
机构：
[1] Sylhet MAG Osmani Med Coll Hosp, Dept Pharmacol, Sylhet 3100, Bangladesh
[2] Sylhet MAG Osmani Med Coll Hosp, Dept Cardiol, Sylhet 3100, Bangladesh
[3] NE Med Coll, Dept Biochem, Sylhet 3100, Bangladesh
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2008年 / 3卷 / 01期
关键词：
Diabetes mellitus; Myocardial infarction; Streptokinase;
D O I：
10.3329/bjp.v3i1.822
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A prospective interventional study was carried out to compare the thrombolytic effect of streptokinase between diabetic and nondiabetic myocardial infarction patients. Out of 187 study subjects with acute ST segment elevation myocardial infarction (STEMI), admitted at coronary care unit, 126 patients were non-diabetic and 61 patients were diabetic. Streptokinase was administered to all patients. Resolution (reduction) of elevated ST segment was evaluated after 90 min of streptokinase administration. Successful reperfusion (=70% ST-resolution) was significantly higher in nondiabetic than diabetic (p<0.001), while failed reperfusion (<30% ST resolution) was significantly higher in diabetic patients (p<0.001). It may be concluded that diabetes mellitus might affect the thrombolytic outcome of acute myocardial infarction patients with diabetes mellitus.
引用
收藏
页码：1 / 7
页数：7
相关论文
共 26 条
[1]   Impact of diabetes mellitus on epicardial and microvascular flow after fibrinolytic therapy [J].
Angeja, BG ;
de Lemos, J ;
Murphy, SA ;
Marble, SJ ;
Antman, EM ;
Cannon, CP ;
Braunwald, E ;
Gibson, CM .
AMERICAN HEART JOURNAL, 2002, 144 (04) :649-656
[2]  
Bajzer CT, 2002, MED INDEX, P222
[3]   Implementation of reperfusion therapy in acute myocardial infarction. A policy statement from the European Society of Cardiology [J].
Bassand, JP ;
Danchin, N ;
Filippatos, G ;
Gitt, A ;
Hamm, C ;
Silber, S ;
Tubaro, M ;
Weidinger, F .
EUROPEAN HEART JOURNAL, 2005, 26 (24) :2733-2741
[4]  
BOON MA, 2002, DAVIDSONS PRINCIPLES, P357
[5]   What's the point of ST elevation? [J].
Carley, SD ;
Gamon, R ;
Driscoll, PA ;
Brown, G ;
Wallman, P .
EMERGENCY MEDICINE JOURNAL, 2002, 19 (02) :126-128
[6]   Time to treatment influences the impact of ST-segment resolution on one-year prognosis - Insights from the Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT-2) trial [J].
Fu, YL ;
Goodman, S ;
Chang, WC ;
Van de Werf, F ;
Granger, CB ;
Armstrong, PW .
CIRCULATION, 2001, 104 (22) :2653-2659
[7]   Comparative analysis of the activity and content of different streptokinase preparations [J].
Hermentin, P ;
Cuesta-Linker, T ;
Weisse, J ;
Schmidt, KH ;
Knorst, M ;
Scheld, M ;
Thimme, M .
EUROPEAN HEART JOURNAL, 2005, 26 (09) :933-940
[8]   Impact of diabetes mellitus on long term survival after acute myocardial infarction in patients with single vessel disease [J].
Ishihara, M ;
Sato, H ;
Kawagoe, T ;
Shimatani, Y ;
Kurisu, S ;
Nishioka, K ;
Kouno, Y ;
Umemura, T ;
Nakamura, S .
HEART, 2001, 86 (02) :133-138
[9]   ABILITY OF THE NO-REFLOW PHENOMENON DURING AN ACUTE MYOCARDIAL-INFARCTION TO PREDICT LEFT-VENTRICULAR DYSFUNCTION AT ONE-MONTH FOLLOW-UP [J].
KENNER, MD ;
ZAJAC, EJ ;
KONDOS, GT ;
DAVE, R ;
WINKELMANN, JW ;
JOFTUS, J ;
LAUCEVICIUS, A ;
KYBARSKIS, A ;
BERUKSTIS, E ;
URBONAS, A ;
FEINSTEIN, SB .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 76 (12) :861-868
[10]  
KHANDAKER RK, 1986, BANGLADESH HEART J, V1, P14
123