Updates in the management of connective tissue disease-associated interstitial lung disease

被引：0

作者：

Kavadichanda, Chengappa ^{[1
]}

Naidu, G. S. R. S. N. K. ^{[2
]}

机构：

[1] Jawaharlal Inst Postgrad Med Educ & Res, Dept Clin Immunol, Pondicherry, India

[2] Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh, India

来源：

INDIAN JOURNAL OF RHEUMATOLOGY | 2021年 / 16卷 / 05期

关键词：

Antifibrotic; biologicals; connective tissue disease-interstitial lung disease; treatment; CUTANEOUS SYSTEMIC-SCLEROSIS; STEM-CELL TRANSPLANTATION; DOUBLE-BLIND; PULSE CYCLOPHOSPHAMIDE; SUBGROUP ANALYSIS; OPEN-LABEL; RITUXIMAB; EFFICACY; SAFETY; NINTEDANIB;

D O I：

10.4103/0973-3698.332985

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The occurrence of interstitial lung disease (ILD) in a setting of a well-defined autoimmune disease or in the presence of autoantibodies is being increasingly recognized. The traditional approach to the treatment of connective tissue disease-associated ILD (CTD-ILD) was a combination of glucocorticoids and cyclophosphamide or mycophenolate mofetil. Most of the evidence in treating these cases is limited to a few trials in scleroderma and idiopathic pulmonary fibrosis along with several observational studies in other CTDs. Insights into the pathology of these diseases and the associated lung involvement have resulted in the emergence of several immunosuppressive, antifibrotic, and small molecules as alternatives in CTD-ILD. In this review, we have attempted to summarize several emerging therapeutic options for CTD-ILD.

引用

页码：109 / 115

页数：7

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