Cumyl:: A better N-protecting group of α-diazo acetamides for intra-molecular C-H insertion reaction and its application in the synthesis of pregabalin and 3-benzyloxy pyrrolidine

被引：25

作者：

Chen, ZL

Chen, ZY

Jiang, YZ

Hu, WH ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth Chirotechnol Sichuan Provi, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Organ Chem, Union Lab Aymmetr Synth, Chengdu 610041, Peoples R China

来源：

SYNLETT | 2004年 / 10期

关键词：

cumyl; C-H insertion; pregabalin; pyrrolidine;

D O I：

10.1055/s-2004-829568

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Via intramolecular C-H insertion of N-cumyl alpha-diazo acetamides, gamma-lactams were efficiently synthesized with excellent regioselectivity. A concise route for the preparation of pregabalin (79% overall yield) and 3-benzyloxy pyrrolidine (21% overall yield) were reported.

引用

页码：1763 / 1764

页数：2

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