A simple synthesis of (+)- and (-)-alkaloid 241D and C-4 epimers

被引：46

作者：

Ciblat, S ^{[1
]}

Calinaud, P ^{[1
]}

Canet, JL ^{[1
]}

Troin, Y ^{[1
]}

机构：

[1] Univ Blaise Pascal, Ecole Natl Super Chim Clermont Ferrand, Lab Chim Heterocycles & Glucides, EA 987, F-63174 Aubiere, France

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 03期

关键词：

D O I：

10.1039/a908265d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective preparation of both enantiomers of alkaloid 241D 1 and its C-4 epimer is reported. This simple and concise synthesis, seven steps from pent-3-en-2-one, involves a highly diastereoselective Mannich-type cyclisation as the key step.

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页码：353 / 357

页数：5

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