Biotechnical Micro-Flow PrOcessing at the EDGE - Lessons to be learnt for a Young Discipline

被引:23
作者
Hessel, V. [1 ]
Tibhe, J. [1 ]
Noel, T. [1 ]
Wang, Q. [1 ]
机构
[1] Eindhoven Univ Technol, Dept Chem Engn & Chem, POB 513, NL-5600 MB Eindhoven, Netherlands
基金
欧洲研究理事会;
关键词
microreactors; enzymes; enzymatic microreactors; chemical intensification; process-design intensification; ENZYME-CATALYZED REACTIONS; USER ACCEPTANCE; PLANT CONCEPTS; STEROID BIOTRANSFORMATION; REGIOSELECTIVE ACYLATION; CAPILLARY MICROREACTOR; MICROCHANNEL SYSTEM; LIPASE; IMMOBILIZATION; GLYCOSYLATION;
D O I
10.15255/CABEQ.2014.1939
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
EDGE denotes "Explain, Demonstrate, Guide, Enable" and comes from a concept for youth leadership development training. Biotechnical and,enzymatic micro-flow reactors, are a young discipline. Here the enthusiasm level mirrors its technological growth and vice versa. Rather than being a linear function, enthusiasm first goes down after sudden realization of all bottlenecks and technological shortcomings which are to overcome in a Hercules task action. However, with increasing provision of technology and security in its performance, the enthusiasm level rises again. This "valley of death" needs to be crossed to bridge to a market. The enzymatic micro-flow reactors mirror the above depicted development of their counterparts the chemical microreactors which is already about 20 years old. This "Deja vu" forms a feature story which encompasses a review about enzymatic microreactors and their synthetic applications which are shown in all their facets. This compilation is structured in chapters about reactor and enzyme support technology, transport intensification, chemical intensification, process-design intensification, and finally first steps into the bio-based economy.
引用
收藏
页码:167 / 188
页数:22
相关论文
共 76 条
[1]   The development of a capillary microreactor for transesterification reactions using lipase immobilized onto a silica monolith [J].
Anuar, Sabiqah Tuan ;
Zhao, Yuan-Yuan ;
Mugo, Samuel M. ;
Curtis, Jonathan M. .
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2013, 92 :62-70
[2]   Enzyme-Immobilized Microfluidic Process Reactors [J].
Asanomi, Yuya ;
Yamaguchi, Hiroshi ;
Miyazaki, Masaya ;
Maeda, Hideaki .
MOLECULES, 2011, 16 (07) :6041-6059
[3]   Continuous-Flow Reactor-Based Enzymatic Synthesis of Phosphorylated Compounds on a Large Scale [J].
Babich, Lara ;
Hartog, Aloysius F. ;
van der Horst, Michael A. ;
Wever, Ron .
CHEMISTRY-A EUROPEAN JOURNAL, 2012, 18 (21) :6604-6609
[4]   Immobilization of trypsin via graphene oxide-silica composite for efficient microchip proteolysis [J].
Bao, Huimin ;
Zhang, Luyan ;
Chen, Gang .
JOURNAL OF CHROMATOGRAPHY A, 2013, 1310 :74-81
[5]   Multiphase biotransformations in microstructured reactors: opportunities for biocatalytic process intensification and smart flow processing [J].
Bolivar, Juan M. ;
Nidetzky, Bernd .
GREEN PROCESSING AND SYNTHESIS, 2013, 2 (06) :541-559
[6]   Biotransformations in microstructured reactors: more than flowing with the stream? [J].
Bolivar, Juan M. ;
Wiesbauer, Johanna ;
Nidetzky, Bernd .
TRENDS IN BIOTECHNOLOGY, 2011, 29 (07) :333-342
[7]   Studying enzymatic bioreactions in a millisecond microfluidic flow mixer [J].
Buchegger, Wolfgang ;
Haller, Anna ;
van den Driesche, Sander ;
Kraft, Martin ;
Lendl, Bernhard ;
Vellekoop, Michael .
BIOMICROFLUIDICS, 2012, 6 (01)
[8]   Oligosaccharide synthesis in microreactors [J].
Carrel, Frederic R. ;
Geyer, Karolin ;
Codee, Jeroen D. C. ;
Seeberger, Peter H. .
ORGANIC LETTERS, 2007, 9 (12) :2285-2288
[9]   Glucose level determination with a multi-enzymatic cascade reaction in a functionalized glass chip [J].
Costantini, Francesca ;
Tiggelaar, Roald ;
Sennato, Simona ;
Mura, Francesco ;
Schlautmann, Stefan ;
Bordi, Federico ;
Gardeniers, Han ;
Manetti, Cesare .
ANALYST, 2013, 138 (17) :5019-5024
[10]  
Darvas F, 2014, GRADUATE TXB FLOW CH