The role of tubulointerstitial injury in chronic renal failure

被引：148

作者：

Becker, GJ ^{[1
]}

Hewitson, TD ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Dept Nephrol, Parkville, Vic 3050, Australia

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2000年 / 9卷 / 02期

关键词：

D O I：

10.1097/00041552-200003000-00006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Progressive renal failure results from a triad of glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. The mechanisms by which tubules are injured, and by which the tubular epithelial cell then excites interstitial inflammation culminating in fibroblast activation and fibrosis have become increasingly understood. Most current methods to prevent progressive glomerulosclerosis would inherently prevent tubular injury and interstitial fibrosis. The behaviour and control of the renal fibroblast is being investigated, with the potential for direct interference with its functions. Curr Opin Nephrol Hypertens 9:133-138. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：133 / 138

页数：6

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