The burden of the HIV viral load and of cell-to-cell spread in HIV/HCV coinfection

被引：4

作者：

Carvalho, Ana R. M. ^{[1
]}

Pinto, Carla M. A. ^{[2
]}

机构：

[1] Univ Porto, Fac Sci, Rua Campo Alegre S-N, P-4440452 Porto, Portugal

[2] Polytech Porto, Sch Engn, Rua Dr Antonio Bernardino de Almeida 431, P-4200072 Porto, Portugal

来源：

IFAC PAPERSONLINE | 2018年 / 51卷 / 02期

关键词：

HIV; HCV; coinfection; cell-to-cell transmission; fractional order model; FRACTIONAL-ORDER MODEL; DRUG-RESISTANCE; DYNAMICS; HCV; TRANSMISSION;

D O I：

10.1016/j.ifacol.2018.03.063

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

We study the burden of the HIV viral load and of the cell-to-cell transmission on the dynamics of a fractional model for HIV/HCV coinfection. The model includes treatment for HCV. We calculate the reproduction number of the model and the local stability of the disease free equilibrium. Simulations of the model reveal the effect of the HIV viral load, of cell-to-cell transmission, and of the order of the fractional derivative on the dynamics of the coinfection. The results are explained using an epidemiological approach. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

引用

页码：367 / 372

页数：6

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