Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

被引：225

作者：

Maisonneuve, Charles ^{[1
]}

Bertholet, Sylvie ^{[2
]}

Philpott, Dana J. ^{[1
]}

De Gregorio, Ennio ^{[2
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[2] Novartis Vaccines & Diagnost, I-53100 Siena, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 34期

关键词：

NOD1; NOD2; NLRP3; TLR4; alum; BACTERIAL MURAMYL DIPEPTIDE; ACTIVATED PROTEIN-KINASE; DENDRITIC CELLS; NLRP3; INFLAMMASOME; ALUMINUM-HYDROXIDE; NALP3; HOST RECOGNITION; CUTTING EDGE; URIC-ACID; PEPTIDOGLYCAN;

D O I：

10.1073/pnas.1400478111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Innate immunity confers an immediate nonspecific mechanism of microbial recognition through germ line-encoded pattern recognition receptors (PRRs). Of these, Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) have shaped our current understanding of innate regulation of adaptive immunity. It is now recognized that PRRs are paramount in instructing an appropriate adaptive immune response. Their ligands have been the focus of adjuvant research with the goal of generating modern vaccine combinations tailored to specific pathogens. In this review we will highlight the recent findings in the field of adjuvant research with a particular focus on the potential of TLR and NLR ligands as adjuvants and their influence on adaptive immune responses.

引用

页码：12294 / 12299

页数：6

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