Microwave-accelerated SPOT-synthesis on cellulose supports

被引：65

作者：

Bowman, MD ^{[1
]}

Jeske, RC ^{[1
]}

Blackwell, HE ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1021/ol049313f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We demonstrate that microwave irradiation can dramatically accelerate reaction rates for spatially addressable library synthesis on planar membrane supports. The development of a robust support/linker system, microwave-assisted synthesis of small molecule test libraries, and methods for solid-phase scale-up on cellulose are described.

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页码：2019 / 2022

页数：4

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