In vivo animal studies with sugammadex

被引：13
作者：
Booij, L. H. D. J. [1 ]
van Egmond, J. [1 ]
Driessen, J. J. [1 ]
de Boer, H. D. [2 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Anaesthesiol, NL-6525 ED Nijmegen, Netherlands
[2] Martini Ziekenhuis, Groningen, Netherlands
来源：
ANAESTHESIA | 2009年 / 64卷
关键词：
ACETYLCHOLINESTERASE INHIBITORS; NEUROMUSCULAR BLOCKADE; REVERSAL AGENTS; ROCURONIUM BROMIDE; RESIDUAL PARALYSIS; PHARMACOKINETICS; CYCLODEXTRINS; DERIVATIVES; VECURONIUM; ORG-25969;
D O I：
10.1111/j.1365-2044.2008.05869.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
A review is presented of animal studies of the selective steroidal neuromuscular blocking drug binding agent sugammadex. These studies demonstrate that sugammadex is faster in onset than the currently used acetylcholinesterase inhibitors, has no muscarinic effects, and is characterised by lack of adverse effects on other organs. These results offer support for the future development of sugammadex for clinical use in humans.
引用
收藏
页码：38 / 44
页数：7
相关论文
共 35 条
  • [11] Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block
    Clark, JK
    Cowley, P
    Muir, AW
    Palin, R
    Pow, E
    Prosser, AB
    Taylor, R
    Zhang, MQ
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (18) : 2565 - 2568
  • [12] Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation
    de Boer, H. D.
    van Egmond, J.
    van de Pol, F.
    Bom, A.
    Driessen, J. J.
    Booij, L. H. D. J.
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2006, 97 (05) : 681 - 686
  • [13] Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys
    de Boer, HD
    van Egmond, J
    van de Pol, F
    Bom, A
    Booij, LHDJ
    [J]. ANESTHESIOLOGY, 2006, 104 (04) : 718 - 723
  • [14] Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys
    de Boer, HD
    van Egmond, J
    van de Poll, F
    Bom, A
    Booij, LHDJ
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2006, 96 (02) : 201 - 206
  • [15] Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey
    de Boer, HD
    van Egmond, J
    van de Pol, F
    Bom, A
    Booij, LHDJ
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2006, 96 (04) : 473 - 479
  • [16] Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969
    Epemolu, O
    Bom, A
    Hope, F
    Mason, R
    [J]. ANESTHESIOLOGY, 2003, 99 (03) : 632 - 637
  • [17] Liquid chromatography/mass spectrometric bioanalysis of a modified γ-cyclodextrin (Org 25969) and Rocuronium bromide (Org 9426) in guinea pig plasma and urine:: its application to determine the plasma pharmacokinetics of Org 25969
    Epemolu, O
    Mayer, I
    Hope, F
    Scullion, P
    Desmond, P
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (20) : 1946 - 1952
  • [18] Recovery from neuromuscular blockade: a survey of practice
    Grayling, M.
    Sweeney, B. P.
    [J]. ANAESTHESIA, 2007, 62 (08) : 806 - 809
  • [19] GRIFFITHS H.R., 1942, ANESTHESIOLOGY, V3, P418, DOI 10.1097/00000542-194207000-00006
  • [20] Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block
    Grove, SJA
    Kaur, J
    Muir, AW
    Pow, E
    Tarver, GJ
    Zhang, MQ
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (02) : 193 - 196
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