In vivo animal studies with sugammadex

被引：13

作者：

Booij, L. H. D. J. ^{[1
]}

van Egmond, J. ^{[1
]}

Driessen, J. J. ^{[1
]}

de Boer, H. D. ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Anaesthesiol, NL-6525 ED Nijmegen, Netherlands

[2] Martini Ziekenhuis, Groningen, Netherlands

来源：

ANAESTHESIA | 2009年 / 64卷

关键词：

ACETYLCHOLINESTERASE INHIBITORS; NEUROMUSCULAR BLOCKADE; REVERSAL AGENTS; ROCURONIUM BROMIDE; RESIDUAL PARALYSIS; PHARMACOKINETICS; CYCLODEXTRINS; DERIVATIVES; VECURONIUM; ORG-25969;

D O I：

10.1111/j.1365-2044.2008.05869.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

A review is presented of animal studies of the selective steroidal neuromuscular blocking drug binding agent sugammadex. These studies demonstrate that sugammadex is faster in onset than the currently used acetylcholinesterase inhibitors, has no muscarinic effects, and is characterised by lack of adverse effects on other organs. These results offer support for the future development of sugammadex for clinical use in humans.

引用

页码：38 / 44

页数：7

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