Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil

被引：18
作者：
Contreras Mejia, Matilde del Carmen [1 ]
Dos Santos, Maisa Porto [1 ,5 ]
Villarouco da Silva, George Allan [1 ,2 ]
Passos, Isabella da Motta [1 ,6 ]
Naveca, Felipe Gomes [2 ]
Souza Cunha, Maria da Graca [3 ]
Moraes, Milton Ozorio [4 ]
de Paula, Lucia [1 ,7 ]
机构：
[1] Univ Fed Amazonas, Programa Posgrad Imunol Basica & Aplicada, Manaus, Amazonas, Brazil
[2] Fundacao Oswaldo Cruz Inst Leonidas & Maria Deane, Manaus, Amazonas, Brazil
[3] Fundacao Alfredo da Matta, Manaus, Amazonas, Brazil
[4] Fiocruz MS, Inst Oswaldo Cruz, Lab Hanseniase, Manaus, Amazonas, Brazil
[5] Inst Nacl de Pesquisas da Amazonia, Lab Micobacteriol, Manaus, Amazonas, Brazil
[6] Univ Estadual Amazonas, Manaus, Amazonas, Brazil
[7] Univ Fed Goias, Dept Ciencias Biol, Reg Catalao, Catalao, Go, Brazil
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 12期
关键词：
MUTATIONS; OFLOXACIN; DAPSONE;
D O I：
10.1128/JCM.01688-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The aim of this study was to identify polymorphisms in the folp1, gyrA, and rpoB genes in leprosy patients treated in Amazonas State, Brazil. Among 197 slit-skin smear samples from untreated or relapsed patients, we found three cases of primary resistance to rifampin and one confirmed case of multidrug resistance.
引用
收藏
页码：4359 / 4360
页数：2
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