Chronic hepatitis B in hepatocarcinogenesis

被引：64
作者：
Park, N. H.
Song, I. H.
Chung, Y-H
机构：
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med,Div Gastroenterol, Seoul 138736, South Korea
[2] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med,Div Gastroenterol, Ulsan 680749, South Korea
[3] Dankook Univ Coll Med, Dept Internal Med, Div Gastroenterol, Cheonan, South Korea
来源：
POSTGRADUATE MEDICAL JOURNAL | 2006年 / 82卷 / 970期
关键词：
D O I：
10.1136/pgmj.2006.047431
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a wide geographical variation. Eighty per cent of HCC is attributed to hepatitis B virus (HBV). The predominant carcinogenic mechanism of HBV associated HCC is through the process of liver cirrhosis, but direct oncogenic effects of HBV may also contribute. Prevention of HBV infections as well as effective treatment of chronic hepatitis B is still needed for the global control of HBV associated HCC. Continued investigation of the mechanisms of hepatocarcinogenesis will refine our current understanding of the molecular and cellular basis for neoplastic transformation in the liver.
引用
收藏
页码：507 / 515
页数：9
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