Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma

被引：19

作者：

Carpentier, C.

Laigle-Donadey, F.

Marie, Y.

Auger, N.

Benouaich-Amiel, A.

Lejeune, J.

Kaloshi, G.

Delattre, J. -Y.

Thillet, J.

Sanson, M.

机构：

[1] Grp Hosp Pitie Salpetriere, Serv Neurol Mazarin, F-75013 Paris, France

[2] Univ Paris 06, Fac Med, INSERM, U711, Paris, France

[3] Hop La Pitie Salpetriere, Serv Neurol Mazarin, Paris, France

来源：

NEUROLOGY | 2006年 / 67卷 / 05期

关键词：

NERVOUS-SYSTEM; GLIOMAS; TUMORS;

D O I：

10.1212/01.wnl.0000229927.12007.37

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.

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收藏

页码：872 / 874

页数：3

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