A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase

被引：12

作者：

Chaturvedula, VSP

Gao, ZJ

Jones, SH

Feng, XZ

Hecht, SM

Kingston, DGI

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA

[3] Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 05期

关键词：

D O I：

10.1021/np030531b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2alpha-hydroxyursolic acid (3), 34-(p-coumaroyl)ursolic acid (4), and beta-sitosteryl-beta-D-galactoside (5). The structure of the new compound 1 was established as 3beta-acetoxy-2alpha-hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase lyase activity.

引用

页码：899 / 901

页数：3

共 19 条

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