Gain-Based Mechanism for pH Sensing Based on Random Lasing

被引：51

作者：

Gaio, Michele ^{[1
]}

Caixeiro, Soraya ^{[1
]}

Marelli, Benedetto ^{[2
,3
]}

Omenetto, Fiorenzo G. ^{[2
]}

Sapienza, Riccardo ^{[1
]}

机构：

[1] Kings Coll London, Dept Phys, London 2LS, England

[2] Tufts Univ, Dept Biomed Engn, 4 Colby St, Medford, MA 02155 USA

[3] MIT, Dept Civil & Environm Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

PHYSICAL REVIEW APPLIED | 2017年 / 7卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

RANDOM LASERS; FLUORESCENCE; CELL;

D O I：

10.1103/PhysRevApplied.7.034005

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Here, we investigate the mechanism of a random-lasing-based sensor which shows pH sensitivity exceeding by 2 orders of magnitude that of a conventional fluorescence sensor. We explain the sensing mechanism as related to gain modifications and lasing-threshold nonlinearities. A dispersive diffusive lasing theory matches the experimental results well, and it allows us to predict the optimal sensing conditions and a maximal sensitivity as large as 200 times that of an identical fluorescence-based sensor. The lack of complex alignment and the high sensitivity make this mechanism promising for future biosensing applications.

引用

页数：6

共 40 条

[1] Twenty-Fold Enhancement of Molecular Fluorescence by Coupling to a J-Aggregate Critically Coupled Resonator [J].