Non-Invasive Electrochemical Biosensors Operating in Human Physiological Fluids

被引：28

作者：

Falk, Magnus ^{[1
,2
]}

Psotta, Carolin ^{[1
,2
,3
]}

Cirovic, Stefan ^{[1
,2
]}

Shleev, Sergey ^{[1
,2
,3
]}

机构：

[1] Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, S-20506 Malmo, Sweden

[2] Malmo Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmo, Sweden

[3] Aptusens AB, S-29394 Kyrkhult, Sweden

来源：

SENSORS | 2020年 / 20卷 / 21期

关键词：

non-invasive biosensors; human physiological fluids; tears; sweat; saliva; urine; POINT-OF-CARE; SALIVARY CORTISOL; BLOOD-GLUCOSE; LABEL-FREE; MOUTHGUARD BIOSENSOR; ALPHA-AMYLASE; CONTACT-LENS; NONENZYMATIC SENSOR; LACTATE DETECTION; ANTIBODY ARRAY;

D O I：

10.3390/s20216352

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Non-invasive healthcare technologies are an important part of research and development nowadays due to the low cost and convenience offered to both healthcare receivers and providers. This work overviews the recent advances in the field of non-invasive electrochemical biosensors operating in secreted human physiological fluids, viz. tears, sweat, saliva, and urine. Described electrochemical devices are based on different electrochemical techniques, viz. amperometry, coulometry, cyclic voltammetry, and impedance spectroscopy. Challenges that confront researchers in this exciting area and key requirements for biodevices are discussed. It is concluded that the field of non-invasive sensing of biomarkers in bodily fluid is highly convoluted. Nonetheless, if the drawbacks are appropriately addressed, and the pitfalls are adroitly circumvented, the approach will most certainly disrupt current clinical and self-monitoring practices.

引用

页码：1 / 28

页数：28

共 189 条

[1] Accuracy and trending of non-invasive hemoglobin measurement during different volume and perfusion statuses [J].

Adel, Abdelmoneim ;

Awada, Wael ;

Abdelhamid, Bassant ;

Omar, Heba ;

Abd El Dayem, Omnia ;

Hasanin, Ahmed ;

Rady, Ashraf .

JOURNAL OF CLINICAL MONITORING AND COMPUTING, 2018, 32 (06) :1025-1031

[2]

Agarwal S., 2002, TXB OPHTHALMOLOGY, P3000

[3] Novel Impedimetric Irnmunosensor for Detection of Pathogenic Bacteria Streptococcus pyogenes in Human Saliva [J].

Ahmed, Asif ;

Rushworth, Jo V. ;

Wright, John D. ;

Millner, Paul A. .

ANALYTICAL CHEMISTRY, 2013, 85 (24) :12118-12125

[4]

Ahrens T., 1999, PULSE OXIMETRY, P87

[5] Highly Stretchable and Sensitive Strain Sensor Based on Silver Nanowire-Elastomer Nanocomposite [J].

Amjadi, Morteza ;

Pichitpajongkit, Aekachan ;

Lee, Sangjun ;

Ryu, Seunghwa ;

Park, Inkyu .

ACS NANO, 2014, 8 (05) :5154-5163

[6] A wearable multisensing patch for continuous sweat monitoring [J].

Anastasova, Salzitsa ;

Crewther, Blair ;

Bembnowicz, Pawel ;

Curto, Vincenzo ;

Ip, Henry M. D. ;

Rosa, Bruno ;

Yang, Guang-Zhong .

BIOSENSORS & BIOELECTRONICS, 2017, 93 :139-145

[7] A Highly Sensitive Nonenzymatic Glucose Biosensor Based on the Regulatory Effect of Glucose on Electrochemical Behaviors of Colloidal Silver Nanoparticles on MoS2 [J].

Anderson, Kash ;

Poulter, Benjamin ;

Dudgeon, John ;

Li, Shu-En ;

Ma, Xiang .

SENSORS, 2017, 17 (08)

[8] Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid [J].

Andoralov, Viktor ;

Shleev, Sergey ;

Arnebrant, Thomas ;

Ruzgas, Tautgirdas .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2013, 405 (11) :3871-3879

[9] Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor [J].

Arakawa, Takahiro ;

Kuroki, Yusuke ;

Nitta, Hiroki ;

Chouhan, Prem ;

Toma, Koji ;

Sawada, Shin-ichi ;

Takeuchi, Shuhei ;

Sekita, Toshiaki ;

Akiyoshi, Kazunari ;

Minakuchi, Shunsuke ;

Mitsubayashi, Kohji .

BIOSENSORS & BIOELECTRONICS, 2016, 84 :106-111

[10] A new nano-optical sensor thin film cadmium sulfide doped in sol-gel matrix for assessment of α-amylase activity in human saliva [J].

Attia, M. S. ;

Zoulghena, H. ;

Abdel-Mottaleb, M. S. A. .

ANALYST, 2014, 139 (04) :793-800

← 1 2 3 4 5 6 7 8 9 10 →