Three-dimensional cellular automaton simulation of tumour growth in inhomogeneous oxygen environment

被引：2

作者：

Hotzendorfer, H. ^{[1
]}

Estelberger, W. ^{[1
]}

Breitenecker, F. ^{[2
]}

Wassertheurer, S. ^{[1
]}

机构：

[1] Austrian Res Ctr GmbH ARC Biomed Engn, A-1220 Vienna, Austria

[2] Vienna Univ Technol, Dept Anal & Sci Comp, A-1040 Vienna, Austria

来源：

MATHEMATICAL AND COMPUTER MODELLING OF DYNAMICAL SYSTEMS | 2009年 / 15卷 / 02期

关键词：

cellular automaton; tumour growth; arterial tree; computer simulation; angiogenesis; ARTERIAL TREE; BLOOD-FLOW; DESIGN; MODEL;

D O I：

10.1080/13873950902724155

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Cellular automaton theory has previously been used to study cell growth. In this study, we present a three-dimensional cellular automaton model performing the growth simulation of normal and cancerous cells. The necessary nutrient supply is provided by an artificial arterial tree which is generated by constrained constructive optimization. Spatial oxygen diffusion is approximated again by a cellular automaton model. All results could be illustrated dynamically by three-dimensional volume visualization. Because of the chosen modelling approach, an extension of the model to simulate angiogenic processes is possible.

引用

页码：177 / 189

页数：13

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