Anti leukemic α-pyrone derivatives from the endophytic fungus Alternaria phragmospora

被引：31

作者：

Metwaly, Ahmed M. ^{[1
,2
]}

Fronczek, Frank R. ^{[3
]}

Ma, Guoyi ^{[1
]}

Kadry, Hazem A. ^{[2
]}

El-Hela, Atef A. ^{[2
]}

Mohammad, Abd-Elsalam I. ^{[2
]}

Cutler, Stephen J. ^{[1
,4
]}

Ross, Samir A. ^{[1
,5
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt

[3] Louisiana State Univ, Coll Sci, Dept Chem, Baton Rouge, LA 70803 USA

[4] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[5] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 24期

基金：

美国农业部;

关键词：

Anti leukemic; alpha-Pyrone derivatives; Alternaria phragmospora; Endophytic fungi; METABOLITES;

D O I：

10.1016/j.tetlet.2014.04.085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new (1-4) and two known (5 and 6) alpha-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-buty1-6-(hydroxymethyl)-4-methoxy2H-pyran-2-one (2), 5-(1-hydroxybuty1)-4-methoxy-6-methy1-2H-pyran-2-one (3), 4-methoxy-6methy1-5-(3-oxobuty1)-2H-pyran-2-one (4), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5), and 5-[(2E)-but-2-en-1-y1]-4-methoxy-6-methyl-2H-pyran-2-one (6). Compounds 2 and 4 showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 mu M and against K562 cells with IC50 values of 4.5 and 1.5 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3478 / 3481

页数：4

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