Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

被引:16
作者
Hanberger, Hakan [1 ]
Antonelli, Massimo [2 ]
Holmbom, Martin [1 ]
Lipman, Jeffrey [3 ]
Pickkers, Peter [4 ]
Leone, Marc [5 ]
Rello, Jordi [6 ]
Sakr, Yasser [7 ]
Walther, Sten M. [8 ]
Vanhems, Philippe [9 ]
Vincent, Jean-Louis [10 ]
机构
[1] Linkoping Univ, Fac Hlth Sci, Inst Clin & Expt Med, Div Infect Dis, Linkoping, Sweden
[2] Policlinico Univ A Gemelli, Univ Cattolica Sacro Cuore, Rome, Italy
[3] Univ Queensland, Royal Brisbane & Womens Hosp, Dept Intens Care Med, Herston, Qld, Australia
[4] Radboud Univ Nijmegen Med Ctr, Dept Intens Care Med, Nijmegen, Netherlands
[5] Aix Marseille Univ, AP HM Unite Rech Malad Infectieuses & Transmissib, Hop Nord, Dept Intens Care & Anesthesiol, Marseille, France
[6] Univ Autonoma Barcelona, VHIR, CIBERES, Crit Care Dept,Vall Hebron Univ Hosp, E-08193 Barcelona, Spain
[7] Univ Jena, Dept Anesthesiol & Intens Care, Jena, Germany
[8] Linkoping Univ, Fac Hlth Sci, Dept Med & Hlth, Div Cardiovasc Med, Linkoping, Sweden
[9] Univ Lyon 1, Hosp Civils Lyon, Groupement Hosp Edouard Herriot, Serv Hygiene Epidemiol & Prevent, F-69365 Lyon, France
[10] Univ Libre Bruxelles, Erasme Hosp, Dept Intens Care, Brussels, Belgium
关键词
Infection; Critically ill; Antibiotic; Resistance; STAPHYLOCOCCUS-AUREUS; OUTCOMES; IMPACT; APPROPRIATE; SEPSIS; LENGTH; STAY; COST;
D O I
10.1186/1471-2334-14-513
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Antimicrobial resistance is an increasing concern in ICUs worldwide. Infection with an antibiotic resistant (ABR) strain of an organism is associated with greater mortality than infection with the non-resistant strain, but there are few data assessing whether being admitted to an intensive care unit (ICU) with high levels of antimicrobial resistance is associated with a worse outcome than being admitted to an ICU with low rates of resistance. The aim of this study was, therefore, to compare the characteristics of infections and antibiotic treatments and patient outcomes in patients admitted to ICUs in countries considered as having high levels of antibiotic resistance and those admitted to ICUs in countries considered as having low levels of antibiotic resistance. Methods: Data from the large, international EPIC II one-day point prevalence study on infections in patients hospitalized in ICUs were used. For the current study, we compared the data obtained from patients from two groups of countries: countries with reported MRSA rates of >= 25% (highABR: Greece, Israel, Italy, Malta, Portugal, Spain, and Turkey) and countries with MRSA rates of < 5% (lowABR: Denmark, Finland, Netherlands, Norway, and Sweden). Results: On the study day, 1187/2204 (53.9%) patients in the HighABR ICUs were infected and 255/558 (45.7%) in the LowABR ICUs (P < 0.01). Patients in the HighABR ICUs were more severely ill than those in the LowABR ICUs, as reflected by a higher SAPS II score (35.6 vs 32.7, P < 0.05) and had longer median ICU (12 days vs 5 days) and hospital (24 days vs 16 days) lengths of stay. They also had higher crude ICU (20.0% vs 15.4%) and hospital (27.0% vs 21.5%) mortality rates (both P < 0.05). However, after multivariable adjustment and matched pair analysis there were no differences in ICU or hospital mortality rates between High or LowABR ICU patients overall or among those with infections. Conclusions: Being hospitalized in an ICU in a region with high levels of antimicrobial resistance is not associated per se with a worse outcome.
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页数:9
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