Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)

被引：37
|
作者：
Kuduk, Scott D. [1 ]
Di Marco, Christina N. [1 ]
Chang, Ronald K. [1 ]
DiPardo, Robert M. [1 ]
Cook, Sean P. [2 ]
Cato, Matthew J. [2 ]
Jovanovska, Aneta [2 ]
Urban, Mark O. [2 ]
Leitl, Michael [2 ]
Spencer, Robert H. [2 ]
Kane, Stefanie A. [2 ]
Bilodeau, Mark T. [1 ]
Hartman, George D. [1 ]
Bock, Mark G. [1 ]
机构：
[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA
[2] Pain Res Merck Res Labs, West Point, PA 19486 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 09期
关键词：
Amiloride; Pain; ASIC3; Acidosis; RECEPTOR;
D O I：
10.1016/j.bmcl.2009.03.029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2514 / 2518
页数：5
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