Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)

被引：37

作者：

Kuduk, Scott D. ^{[1
]}

Di Marco, Christina N. ^{[1
]}

Chang, Ronald K. ^{[1
]}

DiPardo, Robert M. ^{[1
]}

Cook, Sean P. ^{[2
]}

Cato, Matthew J. ^{[2
]}

Jovanovska, Aneta ^{[2
]}

Urban, Mark O. ^{[2
]}

Leitl, Michael ^{[2
]}

Spencer, Robert H. ^{[2
]}

Kane, Stefanie A. ^{[2
]}

Bilodeau, Mark T. ^{[1
]}

Hartman, George D. ^{[1
]}

Bock, Mark G. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

[2] Pain Res Merck Res Labs, West Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 09期

关键词：

Amiloride; Pain; ASIC3; Acidosis; RECEPTOR;

D O I：

10.1016/j.bmcl.2009.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2514 / 2518

页数：5

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