Mechanisms and functions of EPH and ephrin signalling

被引:941
作者
Kullander, K [1 ]
Klein, R
机构
[1] AstraZeneca Transgen & Comparat Genom, S-43183 Molndal, Sweden
[2] Max Planck Inst Neurobiol, Dept Mol Neurobiol, D-82152 Martinsried, Germany
关键词
D O I
10.1038/nrm856
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Eph receptors constitute the largest family of tyrosine kinase receptors and, together with their plasma-membrane-bound ephrin ligands, have many important functions during development and adulthood. In contrast with most receptor tyrosine kinases, unidirectional signalling can originate from the ephrin ligands as well as from the Eph receptors. Furthermore, the concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell-cell communication.
引用
收藏
页码:475 / 486
页数:12
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