In the future, the internationalization of higher education is undergoing a series of profound changes. From five aspects, the concept, the trend, the mission, the challenge and the prospect, the article analyzes and expounds the trend and development of the internationalization of higher education in the world and China. In the future, education will be a common cause in the world. Due to the influence of multiple factors, the trend of internationalization of higher education will be further accelerated. The internationalization of higher education will be a new mission for the training of high-level talents facing the future. At the same time, the new challenge to improve the influence of global education reform is also faced. On the basis of expanding the connotation of the internationalization of higher education, we should play the leading role of the main force of the internationalization of higher education, create a wider exchange platform and cooperation space, adapt and promote the reform of the educational paradigm that is happening in the world, and strengthen the guarantee of the policy and conditions. We should correctly understand the new ideas, new trends, new missions and new challenges of the internationalization of higher education, and believe that the opening up of higher education in China will have a broader prospect.(1)