Urinary 8-hydroxy-2′-deoxyguanosine (8-oxodG) level can predict acute renal damage in young children with urinary tract infection

被引：7

作者：

Chien, Jien-Wen ^{[1
,2
,3
]}

Wang, Lien-Yen ^{[4
]}

Cheng, Yu-Shan ^{[2
,3
]}

Tsai, Yi-Giien ^{[1
]}

Liu, Chin-San ^{[2
,3
,5
,6
]}

机构：

[1] Changhua Christian Hosp, Dept Pediat, Changhua 500, Taiwan

[2] Changhua Christian Hosp, Dept Vasc, Changhua 500, Taiwan

[3] Changhua Christian Hosp, Genom Ctr, Changhua 500, Taiwan

[4] Changhua Christian Hosp, Dept Nucl Med, Changhua 500, Taiwan

[5] Changhua Christian Hosp, Dept Neurol, Changhua 500, Taiwan

[6] China Med Univ, Coll Chinese Med, Grad Inst Integrat Med, Taichung, Taiwan

来源：

BIOMARKERS | 2014年 / 19卷 / 04期

关键词：

8-hydroxy-2 '-deoxyguanosine; Tc99m-dimercaptosuccinic acid; total antioxidant capacity; urinary tract infection; OXIDATIVE STRESS; ACUTE PYELONEPHRITIS; TISSUE-INJURY; CORTICAL SCINTIGRAPHY; REFLUX NEPHROPATHY; ESCHERICHIA-COLI; DIAGNOSIS; 8-OHDG; MODEL; DNA;

D O I：

10.3109/1354750X.2014.910552

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: There are no good biomarkers to predict renal parenchymal involvement in children with urinary tract infection (UTI). Methods: Children (N = 73) younger than 5 years with UTI were enrolled. Urinary levels of 8-hydroxy-2'-deoxyguanosine (8-oxodG) and total antioxidant capacity (TAC) were checked as markers of oxidative stress and antioxidant capacity, respectively. Tc99m-dimercaptosuccinic acid (DMSA) renal scintigraphy was used to find evidence of renal involvement. Results: Patients with positive DMSA findings had higher levels of urinary 8-oxodG (p = 0.003) and higher urinary TAC (p = 0.001) than patients with normal DMSA findings. Conclusions: High level of urinary 8-oxodG may be a risk factor of severe renal damage.

引用

页码：326 / 331

页数：6

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