P2Y2 receptor agonists -: A new class of medication targeted at improved mucociliary clearance

被引：28
作者：
Kellerman, DJ [1 ]
机构：
[1] Inspire Pharmaceut, Dev, Durham, NC 27703 USA
来源：
CHEST | 2002年 / 121卷 / 05期
关键词：
COPD; chronic bronchitis; cystic fibrosis; INS365; mucociliary clearance; purinergic receptors; P2Y receptors; uridine triphosphate;
D O I：
10.1378/chest.121.5_suppl.201S
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Chronic bronchitis is in part characterized by mucus hypersecretion and the inability, to clear airways of mucus. Despite years of research in this area, to date there are no pharmacologic therapies available to enhance or promote mucociliary clearance. P2Y(2) receptor agonists are a new class of mucoactive compounds that are currently under development for this purpose. This article will review the pharmacology of P2Y(2) receptor agonists, review the clinical studies performed to date, and highlight the challenges inherent in the development of therapies with these pharmacologic properties.
引用
收藏
页码：201S / 205S
页数：5
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