Phase II Results of Ara-C and Idarubicin in Combination with the Selective Inhibitor of Nuclear Export (SINE) Compound Selinexor (KPT-330) in Patients with Relapsed or Refractory AML

被引：9

作者：

Fiedler, Walter ^{[1
]}

Heuser, Michael ^{[2
]}

Chromik, Joerg ^{[3
]}

Thol, Felicitas ^{[2
]}

Bokemeyer, Carsten ^{[4
]}

Theile, Susann ^{[5
]}

Lebkuechner, Isabell ^{[5
]}

Kranich, Anne L. ^{[6
]}

机构：

[1] Univ Hosp Eppendorf, Dept Hematol & Oncol, Hamburg, Germany

[2] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

[3] Univ Hosp Frankfurt, Frankfurt, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Ctr Oncol, Med Clin & Polyclin 2, Hamburg, Germany

[5] GSOmbH, Hamburg, Germany

[6] GSO Global B V, Amsterdam, Netherlands

来源：

BLOOD | 2016年 / 128卷 / 22期

关键词：

D O I：

10.1182/blood.V128.22.341.341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

341

引用

页数：6

共 50 条

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JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)

[33] Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom's Macroglobulinemia (WM) [J].

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[34] Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia [J].

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Cornell, Robert Frank ;

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[36] Results of a phase 2 trial of selinexor, an oral selective inhibitor of nuclear export (SINE) in 114 patients with gynaecological cancers [J].

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[37] Results of a Phase 2 Trial of Selinexor, an Oral Selective Inhibitor of Nuclear Export (SINE) in 114 Patients With Gynaecological Cancers [J].

不详 .

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[38] Results of a phase II trial of selinexor, an oral selective inhibitor of nuclear export (SINE), in patients with metastatic castration resistant prostate cancer (mCRPC) refractory to abiraterone or enzalutamide. [J].

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[39] Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma [J].

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[40] Selective Inhibitor of Nuclear Export Selinexor (KPT-330) and BCL2 Inhibitor ABT-199 Enhance the Anti-Lymphoma Effect of BTK Inhibitor Ibrutinib in Mantle Cell Lymphoma [J].

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