Relationship between survival and age in patients with idiopathic pulmonary fibrosis

被引：10

作者：

Koo, So-My ^{[1
]}

Uh, Soo-Taek ^{[1
]}

Kim, Dong Soon ^{[2
]}

Kim, Young Whan ^{[3
,4
]}

Chung, Man Pyo ^{[5
]}

Park, Choon Sik ^{[6
]}

Jeong, Sung Hwan ^{[7
]}

Park, Yong Bum ^{[8
]}

Lee, Hong Lyeol ^{[9
]}

Shin, Jong Wook ^{[10
]}

Lee, Eun Joo ^{[11
]}

Lee, Jin Hwa ^{[12
]}

Jegal, Yangin ^{[13
]}

Lee, Hyun Kyung ^{[14
]}

Kim, Yong Hyun ^{[15
]}

Song, Jin Woo ^{[2
]}

Park, Moo Suk ^{[16
]}

Hwangbo, Young ^{[17
]}

机构：

[1] Soonchunhyang Univ, Div Allergy & Resp Med, Dept Internal Med, Seoul Hosp, 59 Daesagwan Ro, Seoul 04401, South Korea

[2] Univ Ulsan, Div Pulm & Crit Care Med, Asan Med Ctr, Coll Med, Seoul, South Korea

[3] Seoul Natl Univ, Div Pulm & Crit Care Med, Dept Internal Med, Coll Med, Seoul, South Korea

[4] Seoul Natl Univ, Lung Inst, Coll Med, Seoul, South Korea

[5] Sungkyunkwan Univ, Div Pulm & Crit Care Med, Samsung Med Ctr, Sch Med, Seoul, South Korea

[6] Soonchunhyang Univ, Div Allergy & Resp Med, Dept Internal Med, Bucheon Hosp, Gyeonggi Do, South Korea

[7] Gachon Univ, Gil Med Ctr, Div Pulmonol, Dept Internal Med, Inchon, South Korea

[8] Hallym Univ, Div Pulm Allergy & Crit Care Med, Dept Internal Med, Kangdong Sacred Heart Hosp, Seoul, South Korea

[9] Inha Univ Hosp, Pulm Div, Dept Internal Med, Inchon, South Korea

[10] Chung Ang Univ, Coll Med, Div Pulm Med, Dept Internal Med, Seoul, South Korea

[11] Korea Univ, Div Resp & Crit Care Med, Dept Internal Med, Anam Hosp,Coll Med, Seoul, South Korea

[12] Ewha Womans Univ, Dept Internal Med, Sch Med, Ewha Med Res Inst, Seoul, South Korea

[13] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Div Pulm Med,Dept Internal Med, Ulsan, South Korea

[14] Inje Univ, Div Crit Care & Pulm Med, Dept Internal Med, Pusan Paik Hosp, Gimhae, South Korea

[15] Catholic Univ Korea, Div Allergy & Pulmonol, Dept Internal Med, Bucheon St Marys Hosp,Sch Med, Seoul, South Korea

[16] Yonsei Univ, Yonsei Univ Hlth Syst, Div Pulm & Crit Care Med, Dept Internal Med,Coll Med, Seoul, South Korea

[17] Soonchunhyang Univ, Dept Prevent Med, Coll Med, Cheonan, South Korea

来源：

JOURNAL OF THORACIC DISEASE | 2016年 / 8卷 / 11期

关键词：

Idiopathic pulmonary fibrosis (IPF); age factors; prognosis; survival analysis; relative survival; RELATIVE SURVIVAL; DISEASE; CLASSIFICATION; MORTALITY;

D O I：

10.21037/jtd.2016.11.40

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: There is a debate that older patients with idiopathic pulmonary fibrosis (IPF) have a worse prognosis. We evaluated whether age affects the survival of patients with IPF. Methods: The Korean Interstitial Lung Disease (ILD) Research Group conducted a national survey to evaluate the clinical, physiological, radiological, and survival characteristics of patients with IPF. A total of 1,663 patients with IPF were stratified into three groups according to age: (I) <60 years (n=309); (II) 60-69 years (n=613); and (III) >= 70 years (n=741). Results: The 1-, 3- and5- year observed survival rates were 83.0%, 62.6%, and 49.2% in the total population, respectively. The 1-, 3-, and 5-year relative survival rates were 85.7%, 69.1%, and 58.0% in all patients, respectively. The observed survival rate of the group >= 70 years of age was significantly lower than those of the other groups (P<0.001). In contrast, no significant difference in relative survival rate was detected among the three age groups. Compared with patients less than 60 years of age, patients with above 70 years of age had not increased risk of worse relative survival [P=0.252; hazard ratio (HR), 1.11; 95% confidence interval (CI), 0.76-1.64]. Conclusions: The prognosis of patients above 70 years of age with IPF was not different to that of patients less than 60 years of age, using relative survival rate. Age may not affect survival in patients with IPF.

引用

页码：3255 / 3264

页数：10

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