Indocyanine green for sentinel lymph node detection in early breast cancer: Prospective evaluation of detection rate and toxicity-The FLUOBREAST trial

被引：19

作者：

Ngo, Charlotte ^{[1
]}

Sharifzadehgan, Shervine ^{[2
]}

Lecurieux-Lafayette, Cynthia ^{[2
]}

Belhouari, Houda ^{[3
]}

Rousseau, Dominique ^{[4
]}

Bonsang-Kitzis, Helene ^{[1
]}

Crouillebois, Laurence ^{[3
]}

Balaya, Vincent ^{[5
]}

Oudard, Stephane ^{[3
,6
,7
]}

Lecuru, Fabrice ^{[6
,8
]}

Elaidi, Reza-Thierry ^{[3
]}

机构：

[1] Hop Prive Peupliers, Ramsay Sante, Paris, France

[2] Hop Europeen Georges Pompidou, AP HP, Serv Chirurg Cancerol Gynecolog & Sein, Paris, France

[3] ARTIC Assoc Rech Therapeut Innovantes Cancerol, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Dept Pharm, Paris, France

[5] CHU Vaudois, Serv Gynecol Obstetr & Chirurg Gynecolog & Mammai, Lausanne, Switzerland

[6] Paris Descartes Univ, Fac Med, Paris, France

[7] Hop Europeen Georges Pompidou, AP HP, Serv Oncol Med, Paris, France

[8] Inst Curie, Dept Chirurg Oncol, Paris, France

来源：

BREAST JOURNAL | 2020年 / 26卷 / 12期

关键词：

axillary staging; breast cancer; indocyanine green; sentinel lymph node; ROUTINE AXILLARY DISSECTION; BLUE-DYE; MULTICENTER TRIAL; BIOPSY; FLUORESCENCE; AGREEMENT; IDENTIFICATION; RADIOISOTOPE; GUIDELINE;

D O I：

10.1111/tbj.14100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction Detection of sentinel lymph node in early breast cancer is commonly based on the combination of patent blue dye and a radioisotope 99m Technetium. Each of these two tracers has advantages and disadvantages leading to the development of the use of indocyanine green. Methods We conducted a prospective clinical trial to compare the detection rate of indocyanine green with 99mTe. Each patient undergoing a sentinel lymph node biopsy for an early breast cancer received both indocyanine green and radioisotopes. The trial was registered: FLUOBREAST EudraCT N 2015-000698-11, ClinicalTrials.gov: NCT02875626. Results Among a total of 88 patients, 77 were assessable for a total of 205 nodes. Detection rates were 93% for the isotope and 96% for the indocyanine green. The combined detection rate was 99%. The overall concordance rate per patient was 91%. The median number of excised sentinel nodes was 2.3 for each tracer and 2.7 for the combined method (P = .21). All the macrometastatic nodes were detected by both indocyanine green and radioisotopes. The median time between incision of the axilla and removal of the last node was 14 minutes. There was neither allergy nor radio-sensitization linked with the use of indocyanine green. Conclusions Indocyanine green delivers a high detection rate and sensitivity for the sentinel lymph node biopsy in early breast cancer, with short operative time and a normal number of excised sentinel lymph nodes. Allergy is extremely rare and there is no toxicity. Indocyanine green could be an alternative to radioisotopes to provide an accurate staging of the axilla. Its routine use should be approved.

引用

页码：2357 / 2363

页数：7

共 35 条

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