Two new benzophenones and one new natural amide alkaloid isolated from a mangrove-derived Fungus Penicillium citrinum

被引：31

作者：

Zheng, Cai-Juan ^{[1
]}

Liao, Hai-Xia ^{[1
,2
,3
]}

Mei, Rong-Qing ^{[1
]}

Huang, Guo-Lei ^{[1
]}

Yang, Lu-Jia ^{[2
,3
]}

Zhou, Xue-Ming ^{[1
]}

Shao, Tai-Ming ^{[1
,4
]}

Chen, Guang-Ying ^{[1
]}

Wang, Chang-Yun ^{[2
,3
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem, Minist Educ, Haikou, Hainan, Peoples R China

[2] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao, Shandong, Peoples R China

[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China

[4] Hainan Inst Sci & Technol, Coll Chem & Mat Engn, Haikou, Hainan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Penicillium citrinum; penibenzophenone; amide alkaloid; cytotoxic activity; antibacterial activity; DERIVATIVES; GROWTH; POLYKETIDES; METABOLITES; ACID;

D O I：

10.1080/14786419.2018.1460832

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new compounds penibenzophenones A-B (1-2), and the synthetic alpha,beta-unsaturated amide alkaloid (E)-tert-butyl(3-cinnamamidopropyl)carbamate (4), newly identified as a natural product, alone with three known ones (3, 5-6) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound 1 was a chlorinated benzophenone. The structures of 1-6 were elucidated by extensive NMR spectral interpretation, MS data and X-ray analysis. The new compound 2 displayed cytotoxic activity against human A549 cell lines with an IC50 value of 15.7 mu g/mL, and 1 showed antibacterial activity against Staphylococcus aureus with a MIC value of 20 mu g/mL. [GRAPHICS] .

引用

页码：1127 / 1134

页数：8

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