Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s)

被引：106

作者：

Basu, Kingshuk ^{[1
]}

Baral, Abhishek ^{[1
]}

Basak, Shibaji ^{[1
]}

Dehsorkhi, Ashkan ^{[2
]}

Nanda, Jayanta ^{[3
]}

Bhunia, Debmalya ^{[4
]}

Ghosh, Surajit ^{[4
]}

Castelletto, Valeria ^{[2
]}

Hamley, Ian W. ^{[2
]}

Banerjee, Arindam ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, India

[2] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

[3] Ben Gurion Univ Negev, Dept Chem, Beer Sheva, Israel

[4] CSIR Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 28期

基金：

英国工程与自然科学研究理事会;

关键词：

SUPRAMOLECULAR HYDROGELS; SUSTAINED-RELEASE; PHYSIOLOGICAL PH; BETA-SHEET; GEL; DOXORUBICIN; ENCAPSULATION; DELIVERY; NANOSTRUCTURES; BIOMATERIALS;

D O I：

10.1039/c6cc01744d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating D-amino acid residues, indicating their potential use for drug delivery in the future.

引用

页码：5045 / 5048

页数：4

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