Paracetamol Serum Concentrations in Neonates Treated Enterally for Ductal Closure: A Pilot Study

被引：15

作者：

Bin-Nun, Alona ^{[1
]}

Fink, Daniel ^{[1
]}

Mimouni, Francis B. ^{[1
,2
]}

Algur, Nurit ^{[1
]}

Hammerman, Cathy ^{[1
,3
]}

机构：

[1] Shaare Zedek Med Ctr, Jerusalem, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

来源：

JOURNAL OF PEDIATRICS | 2018年 / 198卷

关键词：

INTRAVENOUS PARACETAMOL; ARTERIOSUS CLOSURE; ORAL PARACETAMOL; PHARMACOKINETICS; IBUPROFEN; INFANTS; SAFETY;

D O I：

10.1016/j.jpeds.2018.01.024

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We determined serum paracetamol concentrations 4 hours after the eighth dose in infants treated enterally for ductal closure. Serum paracetamol concentrations correlated (P = .0026) with ductal response. No patent ductus arteriosus in a baby with paracetamol levels <20 mg/L closed in response to treatment. Paracetamol levels also correlated (P = .046) with postnatal age.

引用

收藏

页码：304 / 307

页数：4

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