Paracetamol Serum Concentrations in Neonates Treated Enterally for Ductal Closure: A Pilot Study

被引：15
作者：
Bin-Nun, Alona [1 ]
Fink, Daniel [1 ]
Mimouni, Francis B. [1 ,2 ]
Algur, Nurit [1 ]
Hammerman, Cathy [1 ,3 ]
机构：
[1] Shaare Zedek Med Ctr, Jerusalem, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
来源：
JOURNAL OF PEDIATRICS | 2018年 / 198卷
关键词：
INTRAVENOUS PARACETAMOL; ARTERIOSUS CLOSURE; ORAL PARACETAMOL; PHARMACOKINETICS; IBUPROFEN; INFANTS; SAFETY;
D O I：
10.1016/j.jpeds.2018.01.024
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We determined serum paracetamol concentrations 4 hours after the eighth dose in infants treated enterally for ductal closure. Serum paracetamol concentrations correlated (P = .0026) with ductal response. No patent ductus arteriosus in a baby with paracetamol levels <20 mg/L closed in response to treatment. Paracetamol levels also correlated (P = .046) with postnatal age.
引用
收藏
页码：304 / 307
页数：4
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