Defensins in Viral Infections

被引：73

作者：

Ding, Jian ^{[1
]}

Chou, Yi-Ying ^{[1
]}

Chang, Theresa L. ^{[1
]}

机构：

[1] NYU, Mt Sinai Sch Med, Div Infect Dis, Dept Med, New York, NY 10029 USA

来源：

JOURNAL OF INNATE IMMUNITY | 2009年 / 1卷 / 05期

关键词：

Antimicrobial peptides; Defensins; Infectious diseases; Viruses; Virus-host cell interactions; HUMAN ALPHA-DEFENSINS; HERPES-SIMPLEX-VIRUS; HUMAN NEUTROPHIL DEFENSINS; HUMAN BETA-DEFENSIN-1 GENE; INFLUENZA-A VIRUS; THETA-DEFENSINS; HIV-1; INFECTION; IN-VITRO; INNATE IMMUNITY; MESSENGER-RNA;

D O I：

10.1159/000226256

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses. The effects of defensins on viral infections appear to be specific to the defensin, virus and target cell. Regulation of viral infection by defensins is achieved by multiple mechanisms. This review focuses on the interplay between defensins and viral infections, the mechanisms of action of defensins and the in vivo studies of the role of defensins in viral infections. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：413 / 420

页数：8

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