Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma

被引：70
作者：
Morris, Mhairi A. [1 ]
Dawson, Christopher W. [1 ]
Young, Lawrence S. [1 ]
机构：
[1] Univ Birmingham, Sch Canc Sci, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
来源：
FUTURE ONCOLOGY | 2009年 / 5卷 / 06期
关键词：
EBV; Epstein-Barr virus; latent membrane protein 1; LMP1; nasopharyngeal carcinoma; NPC; LYMPHOCYTE GROWTH TRANSFORMATION; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; HUMAN EPITHELIAL-CELLS; NF-KAPPA B; GENE-EXPRESSION; FACTOR RECEPTOR; DOWN-REGULATION; SIGNALING PATHWAY; E-CADHERIN; LATENT-MEMBRANE-PROTEIN-1; SUPPRESSES;
D O I：
10.2217/FON.09.53
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although frequently expressed in Epstein-Barr virus (EBV)-positive malignancies, the contribution of the oncogenic latent membrane protein-1 (LMP1) to the pathogenesis of nosopharyngeal carcinoma remains to be fully defined. As a key effector in EBV-driven B-cell transformation in vitro, LMP1 also displays oncogenic properties in rodent fibroblasts, and exhibits similar effects in epithelial cells. LMP1 functions as a viral mimic of the TNFR family member, CD40, engaging a plethora of signaling pathways including: NF-kappa B, JNK/p38 (SAPK), P13-kinase and ERK-MPK, The constitutive activation of these pathways appears central in the ability of LMP1 to induce multiple morphological and phenotypic alterations. Here we review the effects of LMP1 on epithelial cell growth transformation, and its putative role in the pathogenesis of nasopharyngeal carcinoma, focusing on key areas of proliferation, survival, cell motility and invasion.
引用
收藏
页码：811 / 825
页数：15
相关论文
共 130 条
[1]   Regulation of Survivin and CDK4 by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cell lines [J].
Ai, MD ;
Li, LL ;
Zhao, XR ;
Wu, Y ;
Gong, JP ;
Cao, Y .
CELL RESEARCH, 2005, 15 (10) :777-784
[2]   Degradation of the Epstein-Barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway - Targeting via ubiquitination of the N-terminal residue [J].
Aviel, S ;
Winberg, G ;
Massucci, M ;
Ciechanover, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) :23491-23499
[3]  
BAICHWAL VR, 1988, ONCOGENE, V2, P461
[4]   MUC1 and the MUCs: A family of human mucins with impact in cancer biology [J].
Baldus, SE ;
Engelmann, K ;
Hanisch, FG .
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2004, 41 (02) :189-231
[5]   Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].
Bergers, G ;
Brekken, R ;
McMahon, G ;
Vu, TH ;
Itoh, T ;
Tamaki, K ;
Tanzawa, K ;
Thorpe, P ;
Itohara, S ;
Werb, Z ;
Hanahan, D .
NATURE CELL BIOLOGY, 2000, 2 (10) :737-744
[6]   The transmembrane domains of the EBV-Encoded latent membrane protein 1 (LMP1) variant CAO regulate enhanced signalling activity [J].
Blake, SMS ;
Eliopoulos, AG ;
Dawson, CW ;
Young, LS .
VIROLOGY, 2001, 282 (02) :278-287
[7]   EPSTEIN-BARR-VIRUS LATENT GENE-TRANSCRIPTION IN NASOPHARYNGEAL CARCINOMA-CELLS - COEXPRESSION OF EBNA1, LMP1, AND LMP2 TRANSCRIPTS [J].
BROOKS, L ;
YAO, QY ;
RICKINSON, AB ;
YOUNG, LS .
JOURNAL OF VIROLOGY, 1992, 66 (05) :2689-2697
[8]   Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asia [J].
Burrows, JM ;
Bromham, L ;
Woolfit, M ;
Piganeau, G ;
Tellam, J ;
Connolly, G ;
Webb, N ;
Poulsen, L ;
Cooper, L ;
Burrows, SR ;
Moss, DJ ;
Haryana, SM ;
Ng, M ;
Nicholls, JM ;
Khanna, R .
JOURNAL OF VIROLOGY, 2004, 78 (13) :7131-7137
[9]  
Chan ASC, 2000, CANCER RES, V60, P5365
[10]   Frequent chromosome 9p losses in histologically normal nasopharyngeal epithelia from southern Chinese [J].
Chan, ASC ;
To, KF ;
Lo, KW ;
Ding, M ;
Ll, XH ;
Johnson, P ;
Huang, DP .
INTERNATIONAL JOURNAL OF CANCER, 2002, 102 (03) :300-303
12345678910