Lactoferrin: A Glycoprotein Involved in Immunomodulation, Anticancer, and Antimicrobial Processes

被引:71
|
作者
Rascon-Cruz, Quintin [1 ]
Espinoza-Sanchez, Edward A. [1 ]
Siqueiros-Cendon, Tania S. [1 ]
Nakamura-Bencomo, Sayuri I. [1 ]
Arevalo-Gallegos, Sigifredo [1 ]
Iglesias-Figueroa, Blanca F. [1 ]
机构
[1] Univ Autonoma Chihuahua, Fac Ciencias Quim, Lab Biotecnol 1, Circuito Univ S-N Campus Univ 2, Chihuahua 31125, Chihuahua, Mexico
来源
MOLECULES | 2021年 / 26卷 / 01期
关键词
lactoferrin; immune system; anti-cancer activity; antibacterial activity; RECOMBINANT HUMAN LACTOFERRIN; BOVINE LACTOFERRIN; EARLY NEURODEVELOPMENT; GROWTH-PERFORMANCE; BONE REGENERATION; DOPAMINE NEURONS; HEME OXYGENASE-1; CELL-DEATH; PROTEIN; EXPRESSION;
D O I
10.3390/molecules26010205
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lactoferrin is an iron binding glycoprotein with multiple roles in the body. Its participation in apoptotic processes in cancer cells, its ability to modulate various reactions of the immune system, and its activity against a broad spectrum of pathogenic microorganisms, including respiratory viruses, have made it a protein of broad interest in pharmaceutical and food research and industry. In this review, we have focused on describing the most important functions of lactoferrin and the possible mechanisms of action that lead to its function.
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页数:15
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