Lactoferrin: A Glycoprotein Involved in Immunomodulation, Anticancer, and Antimicrobial Processes

被引:71
|
作者
Rascon-Cruz, Quintin [1 ]
Espinoza-Sanchez, Edward A. [1 ]
Siqueiros-Cendon, Tania S. [1 ]
Nakamura-Bencomo, Sayuri I. [1 ]
Arevalo-Gallegos, Sigifredo [1 ]
Iglesias-Figueroa, Blanca F. [1 ]
机构
[1] Univ Autonoma Chihuahua, Fac Ciencias Quim, Lab Biotecnol 1, Circuito Univ S-N Campus Univ 2, Chihuahua 31125, Chihuahua, Mexico
来源
MOLECULES | 2021年 / 26卷 / 01期
关键词
lactoferrin; immune system; anti-cancer activity; antibacterial activity; RECOMBINANT HUMAN LACTOFERRIN; BOVINE LACTOFERRIN; EARLY NEURODEVELOPMENT; GROWTH-PERFORMANCE; BONE REGENERATION; DOPAMINE NEURONS; HEME OXYGENASE-1; CELL-DEATH; PROTEIN; EXPRESSION;
D O I
10.3390/molecules26010205
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lactoferrin is an iron binding glycoprotein with multiple roles in the body. Its participation in apoptotic processes in cancer cells, its ability to modulate various reactions of the immune system, and its activity against a broad spectrum of pathogenic microorganisms, including respiratory viruses, have made it a protein of broad interest in pharmaceutical and food research and industry. In this review, we have focused on describing the most important functions of lactoferrin and the possible mechanisms of action that lead to its function.
引用
收藏
页数:15
相关论文
共 50 条
  • [1] Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host's innate immunity
    Dierick, Matthias
    Vanrompay, Daisy
    Devriendt, Bert
    Cox, Eric
    BIOCHEMISTRY AND CELL BIOLOGY, 2021, 99 (01) : 61 - 65
  • [2] Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis
    Rosa, Luigi
    Cutone, Antimo
    Lepanto, Maria Stefania
    Paesano, Rosalba
    Valenti, Piera
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (09):
  • [3] Immunomodulatory and antimicrobial activity of lactoferrin
    Pawlik, Adrianna
    Sender, Grazyna
    Korwin-Kossakowska, Agnieszka
    Oprzadek, Jolanta
    MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE, 2014, 70 (04): : 209 - 213
  • [4] Lactoferrin: A multifunctional glycoprotein involved in the modulation of the inflammatory process
    Baveye, S
    Elass, E
    Mazurier, J
    Spik, G
    Legrand, D
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 1999, 37 (03) : 281 - 286
  • [5] Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy
    Zhang, Yunlei
    Lima, Cristovao F.
    Rodrigues, Ligia R.
    NUTRITION REVIEWS, 2014, 72 (12) : 763 - 773
  • [6] Selective deglycosylation of lactoferrin to understand glycans' contribution to antimicrobial activity of lactoferrin
    Karav, Sercan
    CELLULAR AND MOLECULAR BIOLOGY, 2018, 64 (09) : 52 - 57
  • [7] Lactoferrin: Antimicrobial activity and therapeutic potential
    Embleton, Nicholas D.
    Berrington, Janet E.
    McGuire, William
    Stewart, Chris J.
    Cummings, Stephen P.
    SEMINARS IN FETAL & NEONATAL MEDICINE, 2013, 18 (03) : 143 - 149
  • [8] Antimicrobial properties of lactoferrin
    Jenssen, Havard
    Hancock, Robert E. W.
    BIOCHIMIE, 2009, 91 (01) : 19 - 29
  • [9] Plasmalemmal V-ATPase as a Potential Biomarker for Lactoferrin-Based Anticancer Therapy
    Santos-Pereira, Catia
    Rodrigues, Ligia R.
    Corte-Real, Manuela
    BIOMOLECULES, 2022, 12 (01)
  • [10] Production of Bioactive Porcine Lactoferrin through a Novel Glucose-Inducible Expression System in Pichia pastoris: Unveiling Antimicrobial and Anticancer Functionalities
    Yen, Chih-Ching
    Wu, Pei-Ying
    Ou-Yang, Huan
    Chen, Hsiao-Ling
    Chong, Kowit-Yu
    Chang, Ro-Lin
    Chen, Chuan-Mu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (03)