Lactoferrin: A Glycoprotein Involved in Immunomodulation, Anticancer, and Antimicrobial Processes

被引：89

作者：

Rascon-Cruz, Quintin ^{[1
]}

Espinoza-Sanchez, Edward A. ^{[1
]}

Siqueiros-Cendon, Tania S. ^{[1
]}

Nakamura-Bencomo, Sayuri I. ^{[1
]}

Arevalo-Gallegos, Sigifredo ^{[1
]}

Iglesias-Figueroa, Blanca F. ^{[1
]}

机构：

[1] Univ Autonoma Chihuahua, Fac Ciencias Quim, Lab Biotecnol 1, Circuito Univ S-N Campus Univ 2, Chihuahua 31125, Chihuahua, Mexico

来源：

MOLECULES | 2021年 / 26卷 / 01期

关键词：

lactoferrin; immune system; anti-cancer activity; antibacterial activity; RECOMBINANT HUMAN LACTOFERRIN; BOVINE LACTOFERRIN; EARLY NEURODEVELOPMENT; GROWTH-PERFORMANCE; BONE REGENERATION; DOPAMINE NEURONS; HEME OXYGENASE-1; CELL-DEATH; PROTEIN; EXPRESSION;

D O I：

10.3390/molecules26010205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lactoferrin is an iron binding glycoprotein with multiple roles in the body. Its participation in apoptotic processes in cancer cells, its ability to modulate various reactions of the immune system, and its activity against a broad spectrum of pathogenic microorganisms, including respiratory viruses, have made it a protein of broad interest in pharmaceutical and food research and industry. In this review, we have focused on describing the most important functions of lactoferrin and the possible mechanisms of action that lead to its function.

引用

页数：15

共 145 条

[1] Lactoferrin a multiple bioactive protein: An overview [J].

Abril Garcia-Montoya, Isui ;

Siqueiros Cendon, Tania ;

Arevalo-Gallegos, Sigifredo ;

Rascon-Cruz, Quintin .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (03) :226-236

[2] Lactoferrin as a Natural Immune Modulator [J].

Actor, Jeffrey K. ;

Hwang, Shen-An ;

Kruzel, Marian L. .

CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (17) :1956-1973

[3] Female perspectives on male involvement in a human-papillomavirus-based cervical cancer-screening program in western Kenya [J].

Adewumi, Konyin ;

Oketch, Sandra Y. ;

Choi, Yujung ;

Huchko, Megan J. .

BMC WOMENS HEALTH, 2019, 19 (01)

[4] Lactoferrin: a review [J].

Adlerova, L. ;

Bartoskova, A. ;

Faldyna, M. .

VETERINARNI MEDICINA, 2008, 53 (09) :457-468

[5] Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates [J].

Alejandra Garcia-Borjas, Karla ;

Ceballos-Olvera, Ivonne ;

Luna-Castro, Sarahi ;

Pena-Avelino, Yosahandy .

PROTEIN AND PEPTIDE LETTERS, 2021, 28 (01) :101-107

[6] Bovine lactoferrin and Crohn's disease: a case study [J].

Alexander, David B. ;

Iigo, Masaaki ;

Abdelgied, Mohamed ;

Ozeki, Keiji ;

Tanida, Satoshi ;

Joh, Takashi ;

Takahashi, Satoru ;

Tsuda, Hiroyuki .

BIOCHEMISTRY AND CELL BIOLOGY, 2017, 95 (01) :133-141

[7] Breastfeeding and Childhood Leukemia Incidence A Meta-analysis and Systematic Review [J].

Amitay, Efrat L. ;

Keinan-Boker, Lital .

JAMA PEDIATRICS, 2015, 169 (06)

[8] Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus [J].

Ammendolia, Maria Grazia ;

Agamennone, Mariangela ;

Pietrantoni, Agostina ;

Lannutti, Fabio ;

Siciliano, Rosa Anna ;

De Giulio, Beatrice ;

Amici, Carla ;

Superti, Fabiana .

PATHOGENS AND GLOBAL HEALTH, 2012, 106 (01) :12-19

[9] Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease [J].

An, Li ;

Sato, Haruhisha ;

Konishi, Yoshihiro ;

Walker, Douglas G. ;

Beach, Thomas G. ;

Rogers, Joseph ;

Tooyama, Ikuo .

NEUROSCIENCE LETTERS, 2009, 452 (03) :277-280

[10] Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against Plasmodium berghei [J].

Anand, Namrata ;

Kanwar, Rupinder K. ;

Sehgal, Rakesh ;

Kanwar, Jagat R. .

NANOMEDICINE, 2016, 11 (01) :47-62

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