Region-specific reduction of auditory sensory gating in older adults

被引：26

作者：

Cheng, Chia-Hsiung ^{[1
,2
,3
]}

Baillet, Sylvain ^{[10
]}

Lin, Yung-Yang ^{[4
,5
,6
,7
,8
,9
]}

机构：

[1] Chang Gung Univ, Dept Occupat Therapy, Taoyuan 333, Taiwan

[2] Chang Gung Univ, Grad Inst Behav Sci, Taoyuan 333, Taiwan

[3] Chang Gung Univ, Hlth Aging Res Ctr, Taoyuan 333, Taiwan

[4] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan

[5] Natl Yang Ming Univ, Inst Physiol, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[7] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan

[8] Taipei Vet Gen Hosp, Neurophysiol Lab, Taipei, Taiwan

[9] Taipei Vet Gen Hosp, Dept Neurol, Taipei, Taiwan

[10] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

来源：

BRAIN AND COGNITION | 2015年 / 101卷

关键词：

Aging; Magnetoencephalography (MEG); Cortical inhibition; Repetition suppression; Paired-pulse suppression; M100; EVENT-RELATED POTENTIALS; TEST-RETEST RELIABILITY; HUMAN CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; MISMATCH NEGATIVITY; PREFRONTAL CORTEX; EVOKED-POTENTIALS; P50; SUPPRESSION; SCHIZOPHRENIA-PATIENTS; COGNITIVE-ABILITIES;

D O I：

10.1016/j.bandc.2015.10.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging has been associated with declines in sensory-perceptual processes. Sensory gating (SG), or repetition suppression, refers to the attenuation of neural activity in response to a second stimulus and is considered to be an automatic process to inhibit redundant sensory inputs. It is controversial whether SG deficits, as tested with an auditory paired-stimulus protocol, accompany normal aging in humans. To reconcile the debates arising from event-related potential studies, we recorded auditory neuromagnetic reactivity in 20 young and 19 elderly adult men and determined the neural activation by using minimum-norm estimate (MNE) source modeling. SG of M100 was calculated by the ratio of the response to the second stimulus over that to the first stimulus. MNE results revealed that fronto-temporo-parietal networks were implicated in the M100 SG. Compared to the younger participants, the elderly showed selectively increased SG ratios in the anterior superior temporal gyrus, anterior middle temporal gyrus, temporal pole and orbitofrontal cortex, suggesting an insufficient age-related gating to repetitive auditory stimulation. These findings also highlight the loss of frontal inhibition of the auditory cortex in normal aging. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：64 / 72

页数：9