Anti-Hyperalgesic Effects of Meloxicam Hydrogel via Phonophoresis in Acute Inflammation in Rats; Comparing Systemic and Topical Application

被引：3

作者：

Kim, Tae-Youl ^{[2
]}

Kim, Young-Il ^{[3
]}

Seo, Sam-Ki ^{[4
]}

Kim, Soo-Hyeun ^{[2
]}

Yang, Kyu-Ho ^{[5
]}

Shin, Sang-Chul ^{[1
]}

机构：

[1] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[2] Dongshin Univ, Dept Phys Therapy, Naju 520714, South Korea

[3] Konyang Univ, Dept Pharmaceut Engn, Nonsan 320711, South Korea

[4] Seonam Univ, Grad Sch, Dept Phys Therapy, Namwon 590711, South Korea

[5] Dent Res Inst & Second Stage BK 21, Sch Dent, Kwangju 500757, South Korea

来源：

BIOMOLECULES & THERAPEUTICS | 2009年 / 17卷 / 03期

关键词：

Meloxicam hydrogel; Phonophoretic transdermal delivery; Anti-hyperalgesia; Systemic application; Topical application; Acute inflammation; DICLOFENAC PHONOPHORESIS; DRUG-DELIVERY; ULTRASOUND; KETOPROFEN; ABSORPTION; ANALGESIA; EFFICACY; ACID;

D O I：

10.4062/biomolther.2009.17.3.305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to determine if a meloxicam hydrogel could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic effects in a rat carrageenan inflammation model. Carrageenan (1%) was injected into the plantar surface of the right hindpaw, and meloxicam hydrogel was administered via phonophoretic transdermal delivery. Changes in the mechanical and thermal hyperalgesia, as well as swelling, showed that phonophoretic delivery of meloxicam exhibited significantly better anti-hyperalgesic and anti-inflammatory effects than pulsed ultrasound. Topical and systemic application of meloxicam hydrogel using phonophoresis showed similar anti-hyperalgesic effects. These findings suggest that the transdermal administration of a meloxicam hydrogel using phonophoresis by pulsed ultrasound might be useful for treating acute inflammation.

引用

页码：305 / 310

页数：6

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