The association between variables of cardiopulmonary exercise test and quality of life in patients with chronic Chagas cardiomyopathy (Insights from the PEACH STUDY)

被引:3
作者
Vieira, Marcelo Carvalho [1 ,2 ]
Nogueira Sardinha Mendes, Fernanda de Souza [1 ]
da Silva, Paula Simplicio [1 ]
Sperandio da Silva, Gilberto Marcelo [1 ]
Mazzoli-Rocha, Flavia [1 ]
de Sousa, Andrea Silvestre [1 ]
Saraiva, Roberto Magalhaes [1 ]
Borges Quintana, Marcel de Souza [1 ]
Costa, Henrique Silveira [3 ]
Paravidino, Vitor Barreto [4 ,5 ]
Rodrigues Junior, Luiz Fernando [6 ,7 ]
Hasslocher-Moreno, Alejandro Marcel [1 ]
Alvarenga Americano do Brasil, Pedro Emmanuel [1 ]
Felix Mediano, Mauro Felippe [1 ,6 ]
机构
[1] Fundacao Oswaldo Cruz, Evandro Chagas Natl Inst Infect Dis, Rio De Janeiro, Brazil
[2] Aloysio de Castro State Inst Cardiol, Ctr Cardiol & Exercise, Rio De Janeiro, Brazil
[3] Fed Univ Jequitinhonha & Mucuri Valleys, Dept Phys Therapy, Diamantina, MG, Brazil
[4] Univ Estado Rio De Janeiro, Inst Social Med, Rio De Janeiro, RJ, Brazil
[5] Naval Acad, Dept Phys Educ & Sports, Rio De Janeiro, Brazil
[6] Natl Inst Cardiol, Dept Res & Educ, Rio De Janeiro, RJ, Brazil
[7] Fed Univ State Rio de Janeiro, Dept Physiol Sci, Rio De Janeiro, RJ, Brazil
来源
PLOS ONE | 2022年 / 17卷 / 12期
关键词
HEART-RATE RECOVERY; 6-MINUTE WALK TEST; FUNCTIONAL-CAPACITY; PROGNOSTIC VALUE; FAILURE; DISEASE; HEALTH; PREDICTORS; MORTALITY; ADULTS;
D O I
10.1371/journal.pone.0279086
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Studies investigating the association between functional capacity and quality of life (QoL) in individuals with chronic Chagas cardiomyopathy (CCC) usually do not include a gold-standard evaluation of functional capacity, limiting the validity and the interpretation of the results. The present study is a cross-section analysis aiming to evaluate the association between functional capacity (quantified by cardiopulmonary exercise test [CPET]) and QoL in individuals with CCC. QoL was assessed using the SF-36 questionnaire. Sociodemographic, anthropometric, clinical, cardiac function and maximal progressive CPET variables were obtained from PEACH study. Generalized linear models adjusted for age, sex, and left ventricular ejection fraction were performed to evaluate the association between CPET variables and QoL. After adjustments, VO2 peak and VO2 AT were both associated with physical functioning (beta = +0.05 and beta = +0.05, respectively) and physical component summary (beta = +0.03 and beta = +0.03, respectively). Double product was associated with physical functioning (beta = +0.003), general health perceptions (beta = +0.003), physical component summary (beta = +0.002), and vitality (beta = +0.004). HRR <= 12bpm was associated with physical functioning (beta = -0.32), role limitations due to physical problems (beta = -0.87), bodily pain (beta = -0.26), physical component summary (beta = -0.21), vitality (beta = -0.38), and mental health (beta = -0.19). VE/VCO2 slope presented association with all mental scales of SF-36: vitality (beta = -0.028), social functioning (beta = -0.024), role limitations due to emotional problems (beta = -0.06), mental health (beta = -0.04), and mental component summary (beta = -0.02). The associations between CPET variables and QoL demonstrate the importance of CPET inclusion for a more comprehensive evaluation of individuals with CCC. In this setting, intervention strategies aiming to improve functional capacity may also promote additional benefits on QoL and should be incorporated as a treatment strategy for patients with CCC.
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页数:16
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