Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy

被引：64
|
作者：
Shafiee, Abbas [1 ,2 ,5 ]
Cavalcanti, Amanda S. [1 ]
Saidy, Navid T. [1 ,6 ]
Schneidereit, Dominik [3 ]
Friedrich, Oliver [3 ]
Ravichandran, Akhilandeshwari [1 ]
De-Juan-Pardo, Elena M. [1 ]
Hutmacher, Dietmar W. [1 ,4 ]
机构：
[1] Queensland Univ Technol QUT, Inst Hlth & Biomed Innovat, Ctr Regenerat Med, Brisbane, Qld 4059, Australia
[2] Univ Queensland, Translat Res Inst, UQ Diamantina Inst, Brisbane, Qld 4102, Australia
[3] Friedrich Alexander Univ Erlangen Nurnberg, Inst Med Biotechnol, Paul Gordan Str 3, D-91052 Erlangen, Germany
[4] Queensland Univ Technol QUT, Training Ctr Addit Biomfg, Australian Res Council ARC, Kelvin Grove, Qld 4059, Australia
[5] Metro North Hosp & Hlth Serv, Herston Biofabricat Inst, Brisbane, Qld 4029, Australia
[6] Univ Queensland, Sch Dent, Herston, Qld, Australia
来源：
BIOMATERIALS | 2021年 / 268卷
关键词：
3D printing; Cryopreservation; Regenerative medicine; Tissue Engineering; Wound care; PERIODONTAL-LIGAMENT; PERIPHERAL-NERVES; GINGIVAL TISSUE; SKIN; REGENERATION; CONTRACTION; SCAFFOLDS; PLATFORM; MODEL;
D O I：
10.1016/j.biomaterials.2020.120558
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Biomimetically designed medical-grade polycaprolactone (mPCL) dressings are 3D-printed with pore architecture and anisotropic mechanical characteristics that favor skin wound healing with reduced scarring. Melt electrowritten mPCL dressings are seeded with human gingival tissue multipotent mesenchymal stem/stromal cells and cryopreserved using a clinically approved method. The regenerative potential of fresh or frozen cell seeded mPCL dressing is compared in a splinted full-thickness excisional wound in a rat model over six weeks. The application of 3D-printed mPCL dressings decreased wound contracture and significantly improved skin regeneration through granulation and re-epithelialization compared to control groups. Combining 3D printed biomimetic wound dressings and precursor cell delivery enhances physiological wound closure with reduced scar tissue formation.
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收藏
页数：16
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