New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

被引：12

作者：

Pezzini, Alessandro ^{[1
]}

Del Zotto, Elisabetta ^{[1
]}

Volonghi, Irene ^{[1
]}

Giossi, Alessia ^{[1
]}

Costa, Paolo ^{[1
]}

Padovani, Alessandro ^{[1
]}

机构：

[1] Univ Brescia, Neurol Clin, Dipartimento Sci Med & Chirurg, I-25100 Brescia, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 07期

关键词：

HMG-CoA reductase inhibitors; stroke; pleiotropic effects; NITRIC-OXIDE SYNTHASE; VASCULAR SMOOTH-MUSCLE; COA REDUCTASE INHIBITOR; COENZYME-A REDUCTASE; ENDOTHELIAL PROGENITOR CELLS; LOW-DENSITY-LIPOPROTEIN; FREE-RADICAL PRODUCTION; INDUCED DOWN-REGULATION; RHO-ASSOCIATED KINASE; SUBVENTRICULAR ZONE;

D O I：

10.2174/138955709788452658

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - "statins" - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - "pleiotropic" - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.

引用

页码：794 / 804

页数：11

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