New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

被引：12

作者：

Pezzini, Alessandro ^{[1
]}

Del Zotto, Elisabetta ^{[1
]}

Volonghi, Irene ^{[1
]}

Giossi, Alessia ^{[1
]}

Costa, Paolo ^{[1
]}

Padovani, Alessandro ^{[1
]}

机构：

[1] Univ Brescia, Neurol Clin, Dipartimento Sci Med & Chirurg, I-25100 Brescia, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 07期

关键词：

HMG-CoA reductase inhibitors; stroke; pleiotropic effects; NITRIC-OXIDE SYNTHASE; VASCULAR SMOOTH-MUSCLE; COA REDUCTASE INHIBITOR; COENZYME-A REDUCTASE; ENDOTHELIAL PROGENITOR CELLS; LOW-DENSITY-LIPOPROTEIN; FREE-RADICAL PRODUCTION; INDUCED DOWN-REGULATION; RHO-ASSOCIATED KINASE; SUBVENTRICULAR ZONE;

D O I：

10.2174/138955709788452658

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - "statins" - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - "pleiotropic" - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.

引用

页码：794 / 804

页数：11

共 50 条

[21] Stress on pleiotropic effects of statins [J].

Mishra, PK .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2006, 29 (05) :861-862

[22] Beneficial Pleiotropic Effects of Statins [J].

Lunder, Mojca ;

Ziberna, Lovro ;

Drevensek, Gorazd ;

Sabovic, Miso .

ZDRAVNISKI VESTNIK-SLOVENIAN MEDICAL JOURNAL, 2011, 80 (01) :39-49

[23] Pleiotropic Effects of Statins: The Role of Eicosanoid Production [J].

Birnbaum, Yochai ;

Ye, Yumei .

CURRENT ATHEROSCLEROSIS REPORTS, 2012, 14 (02) :135-139

[24] Statins and stroke prevention [J].

Amarenco, P ;

Lavallée, P ;

Touboul, PJ .

CEREBROVASCULAR DISEASES, 2004, 17 :81-88

[25] Statins in stroke prevention [J].

Gedikli, Oemer ;

Baykan, Merih .

ANATOLIAN JOURNAL OF CARDIOLOGY, 2008, 8 (03) :217-222

[26] Statins and stroke prevention [J].

Laloux, P .

ACTA NEUROLOGICA BELGICA, 2003, 103 (01) :13-18

[27] Statins in stroke prevention [J].

Amarenco, Pierre ;

Lavallee, Philippa C. ;

Mazighi, Mikael ;

Labreuche, Julien .

FUTURE LIPIDOLOGY, 2008, 3 (03) :319-325

[28] Pleiotropic effects of statins: new therapeutic targets in drug design [J].

Onkar Bedi ;

Veena Dhawan ;

P. L. Sharma ;

Puneet Kumar .

Naunyn-Schmiedeberg's Archives of Pharmacology, 2016, 389 :695-712

[29] Statins and cerebrovascular disease:: New perspectives in stroke prevention [J].

Castilla-Guerra, L. ;

Fernandez-Moreno, M. C. ;

Lopez-Chozas, J. M. ;

Jimenez-Hernandez, M. D. .

REVISTA DE NEUROLOGIA, 2007, 44 (02) :95-100

[30] Endothelial progenitor cells:Exploring the pleiotropic effects of statins [J].

Kully Sandhu ;

Mamas Mamas ;

Robert Butler .

World Journal of Cardiology, 2017, (01) :1-13

← 1 2 3 4 5 →