New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

被引：12
|
作者：
Pezzini, Alessandro [1 ]
Del Zotto, Elisabetta [1 ]
Volonghi, Irene [1 ]
Giossi, Alessia [1 ]
Costa, Paolo [1 ]
Padovani, Alessandro [1 ]
机构：
[1] Univ Brescia, Neurol Clin, Dipartimento Sci Med & Chirurg, I-25100 Brescia, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 07期
关键词：
HMG-CoA reductase inhibitors; stroke; pleiotropic effects; NITRIC-OXIDE SYNTHASE; VASCULAR SMOOTH-MUSCLE; COA REDUCTASE INHIBITOR; COENZYME-A REDUCTASE; ENDOTHELIAL PROGENITOR CELLS; LOW-DENSITY-LIPOPROTEIN; FREE-RADICAL PRODUCTION; INDUCED DOWN-REGULATION; RHO-ASSOCIATED KINASE; SUBVENTRICULAR ZONE;
D O I：
10.2174/138955709788452658
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - "statins" - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - "pleiotropic" - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.
引用
收藏
页码：794 / 804
页数：11
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