A MULTI-COMPONENT ONE-POT SYNTHESIS OF NOVEL (1,3,4-THIADIAZIN-2-YLAMINO)ISOINDOLINE-1,3-DIONES AS ANTIMICROBIAL AGENTS

被引：6

作者：

Khidre, Rizk E. ^{[1
,2
]}

Abdel-Wahab, Bakr F. ^{[3
]}

Awad, Ghada E. A. ^{[4
]}

机构：

[1] Natl Res Ctr, Chem Ind Div, Giza 12622, Egypt

[2] Jazan Univ, Fac Sci, Chem Dept, Jazan, Saudi Arabia

[3] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt

[4] Natl Res Ctr, Chem Nat & Microbial Prod, Giza 12622, Egypt

来源：

HETEROCYCLES | 2017年 / 94卷 / 02期

关键词：

STRUCTURE-BASED DESIGN; DERIVATIVES; MOIETY;

D O I：

10.3987/COM-16-13611

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new (1,3,4-thiadiazin-2-ylamino)isoindoline-1,3-dione derivatives 5, 8, 9, 11a-d, and 13a,b were prepared via one-pot three component reaction of isobenzofuran-1,3-dione 1, thiocarbohydrazide 2 and various alpha-halocarbonyl compounds. The chemical structure of the new compounds was elucidated by spectral analyses and X-ray single crystal technique. The newly synthesized compounds were also evaluated for their in vitro antimicrobial activity, and showed promising results.

引用

页码：314 / 325

页数：12

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