Reaching Green: Heterocycle Synthesis by Transition Metal-Catalyzed C-H Functionalization in Sustainable Medium

被引：54

作者：

Santhoshkumar, Rajagopal ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 40期

关键词：

annulation; C-H activation; green solvents; heterocycles; transition metals; ONE-POT SYNTHESIS; N BOND FORMATION; CROSS-COUPLING REACTIONS; SOLVENT-FREE SYNTHESIS; EFFICIENT SYNTHESIS; DIRECTING GROUP; O BOND; REGIOSELECTIVE SYNTHESIS; OXIDATIVE ANNULATION; INDOLE SYNTHESIS;

D O I：

10.1002/chem.201901026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic C-H functionalization has emerged as an efficient alternative to traditional coupling reactions. However, some of these reactions depend on environmentally harmful solvents, weakening the overall green nature of these methods. As organic processes consume large amount of solvents, the use of less harmful solvents enhance the sustainability of these reactions. Herein, we present an overview of transition metal-catalyzed C-H functionalization reactions for the synthesis of heterocycles in sustainable solvents based on CHEM21 solvent selection guide.

引用

页码：9366 / 9384

页数：19

共 216 条

[1] Cationic Ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water [J].